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. 2023 Nov 17;9(12):e22407.
doi: 10.1016/j.heliyon.2023.e22407. eCollection 2023 Dec.

Symptom clusters and characteristics of cervical cancer patients receiving concurrent chemoradiotherapy: A cross-sectional study

Hao Tie  1   2 , Limei Shi  3 , Li Wang  4 , Xinyu Hao  2 , Hongyan Fang  1 , Lirong Li  1
Affiliations

Symptom clusters and characteristics of cervical cancer patients receiving concurrent chemoradiotherapy: A cross-sectional study

Hao Tie et al. Heliyon. .

Abstract

Background: Cervical cancer patients have a high symptom burden during concurrent chemoradiotherapy (CCRT) and urgently need precise symptom management strategies. Nonetheless, the symptom profile and influencing factors are unclear.

Methods: A total of 234 patients with cervical cancer who underwent CCRT in a tertiary care hospital clinical oncology center in Guangxi Zhuang Autonomous Region from March 2022 to March 2023 were included in the study. The general information questionnaire, M.D. Anderson symptom inventory, Fatigue Scale-14, Pittsburgh Sleep Quality Index, and grip strength test were used for the investigation. Symptom clusters were extracted by exploratory factor analysis, and latent profile analysis was performed using Mplus 8.0 software. Multinomial logistic regression was used to explore the factors influencing the potential categories of symptom clusters.

Results: Exploratory factor analysis extracted four symptom clusters: a fatigue-related symptom cluster, a gastrointestinal-related symptom cluster, a mood-related symptom cluster, and a physical-related symptom cluster, of which the fatigue-related symptom cluster was more severe and was divided into three potential categories: low fatigue-good muscle fitness type (25.63%), general fatigue-moderate muscle fitness type (68.37%) and high fatigue-low muscle fitness type (6%). Multinomial logistic regression analysis showed that hemoglobin levels, tumor stage, absence of complications, and unemployment were factors influencing the fatigue-related symptom cluster in patients undergoing CCRT for cervical cancer.

Conclusions: Cervical cancer patients experience multiple symptom clusters during CCRT. Different characteristics appeared in different clusters. Among them, fatigue-related symptom clusters were more severe and heterogeneous. In clinical practice, we should pay attention to and use high symptom feature predictors, focusing on the core symptoms that play a dominant role, achieving early identification and management, and reducing patients' symptom burden.

Keywords: Cervical cancer; Concurrent chemotherapy; Influencing factors; Latent profile analysis; Symptom clusters.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Flowchart of patient selection.
Fig. 2
Fig. 2
Characteristics of 3 latent categories of fatigue-related symptom clusters.
See this image and copyright information in PMC

References

    1. Siegel R.L., Miller K.D., Fuchs H.E., et al. Cancer statistics, 2022. CA A Cancer J. Clin. 2022;72(1):7–33. - PubMed
    1. Miller K.D., Nogueira L., Devasia T., et al. Cancer treatment and survivorship statistics. CA A Cancer J. Clin. 2022;72(5):409–436. 2022. - PubMed
    1. Zhang Y.F., Fan Y., Zhang P., et al. Cervical cancer recurrence and patient survival after radical hysterectomy followed by either adjuvant chemotherapy or adjuvant radiotherapy with optional concurrent chemotherapy: a systematic review and meta-analysis. Front. Oncol. 2022;12 - PMC - PubMed
    1. Yao G., Qiu J., Zhu F., et al. Survival of patients with cervical cancer treated with definitive radiotherapy or concurrent chemoradiotherapy according to histological subtype: a systematic review and meta-analysis. Front. Med. (Lausanne) 2022;9 - PMC - PubMed
    1. Zhang L., Wang J., Chen T., et al. Symptom clusters and quality of life in cervical cancer patients receiving concurrent chemoradiotherapy: the mediating role of illness perceptions. Front. Psychiatr. 2021;12 - PMC - PubMed

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