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Review
. 2023 Oct-Dec;14(4):289-293.
doi: 10.4103/JAPTR.JAPTR_332_23. Epub 2023 Oct 30.

Genetic polymorphisms associated with sepsis incidence, severity, and outcomes among neonates: A mini-review

Darnifayanti Darnifayanti  1   2 , Muslim Akmal  3 , Syahrun Nur  4 , Sulaiman Yusuf  1   2
Affiliations
Review

Genetic polymorphisms associated with sepsis incidence, severity, and outcomes among neonates: A mini-review

Darnifayanti Darnifayanti et al. J Adv Pharm Technol Res. 2023 Oct-Dec.

Abstract

Genetic variation remains a topic of great interest due to its potential as a risk factor for various diseases. Interactions between genes contribute to diverse phenotypes in response to factors such as infection. The impact of genetic background on susceptibility and clinical outcomes, particularly in neonatal sepsis, has gained recognition. The variability in sepsis susceptibility and outcomes can be attributed to the genetic diversity in coding regions and regulatory elements of genes related to innate immune response. Recent advances in genomics and technology have shed light on genetic polymorphisms among humans, often represented by single-nucleotide polymorphisms (SNPs). These SNPs encode proteins crucial for recognizing and responding to pathogenic bacteria, including Toll-like receptor 4, CD14, tumor necrosis factor-alpha, as well as interleukin-1-10. This literature review specifically discusses the involvement of genetic polymorphism during the pathogenesis stage of sepsis, with an emphasis on previous research findings in neonatal sepsis cases, aiming to discuss the implications of polymorphism in sepsis susceptibility and outcomes.

Keywords: Cytokines; immunology; neonates; polymorphism; sepsis.

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Conflict of interest statement

There are no conflicts of interest.

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