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. 2023 Jan-Dec:20:14799731231221818.
doi: 10.1177/14799731231221818.

Physical activity in idiopathic pulmonary fibrosis: Longitudinal change and minimal clinically important difference

Kazuya Shingai  1 , Toshiaki Matsuda  2 , Yasuhiro Kondoh  2 , Tomoki Kimura  2 , Kensuke Kataoka  2 , Toshiki Yokoyama  2 , Yasuhiko Yamano  2 , Tomoya Ogawa  3 , Fumiko Watanabe  3 , Jun Hirasawa  3 , W Darlene Reid  4   5   6 , Ryo Kozu  1
Affiliations

Physical activity in idiopathic pulmonary fibrosis: Longitudinal change and minimal clinically important difference

Kazuya Shingai et al. Chron Respir Dis. 2023 Jan-Dec.

Abstract

Background and objective: Reference values of physical activity to interpret longitudinal changes are not available in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to define the minimal clinical important difference (MCID) of longitudinal changes in physical activity in patients with IPF.

Methods: Using accelerometry, physical activity (steps per day) was measured and compared at baseline and 6-months follow-up in patients with IPF. We calculated MCID of daily step count using multiple anchor-based and distribution-based methods. Forced vital capacity and 6-minute walk distance were applied as anchors in anchor-based methods. Effect size and standard error of measurement were used to calculate MCID in distribution-based methods.

Results: One-hundred and five patients were enrolled in the study (mean age: 68.5 ± 7.5 years). Step count significantly decreased from baseline to 6-months follow-up (-461 ± 2402, p = .031). MCID calculated by anchor-based and distribution-based methods ranged from 570-1358 steps.

Conclusion: Daily step count significantly declined over 6-months in patients with IPF. MCID calculated by multiple anchor-based and distribution-based methods was 570 to 1358 steps/day. These findings contribute to interpretation of the longitudinal changes of physical activity that will assist its use as a clinical and research outcome in patients with IPF.

Keywords: Accelerometry; exercise; exercise test; idiopathic pulmonary fibrosis; minimal clinically important difference; rehabilitation.

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Conflict of interest statement

Declaration Of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Yasuhiro Kondoh reports advisory board fees and personal fees from Asahi Kasei Pharma Corp., Shionogi & Co.Ltd., and Boehringer Ingelheim Co., Ltd., advisory board fees from Janssen Pharmaceutical K.K., Healios K.K., Chugai Pharmaceutical Co., Ltd., and Taiho Pharmaceutical Co., Ltd., and personal fees from AstraZeneca K.K., Eisai inc., KYORIN Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma, and Novartis Pharma K.K., outside the presentation work. Kensuke Kataoka and Yasuhiko Yamano received lecture fees from Nippon Boehringer, Ingelheim Co., Ltd., outside the submitted work. All other authors declared no conflict of interest.

Figures

Figure 1.
Figure 1.
Scatter plots of change in step count and potential anchors (a), FVC; (b), SGRQ; (c), 6MWD. 6MWD, 6-minute walk distance; FVC, forced vital capacity; SGRQ, St. George’s Respiratory Questionnaire.
Figure 2.
Figure 2.
Box plots of change in step count categorized by changes in FVC (a) and 6MWD (b). 6MWD, 6-minute walk distance; FVC, forced vital capacity.
See this image and copyright information in PMC

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