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. 2024 Mar:229:129-132.
doi: 10.1016/j.amjsurg.2023.12.010. Epub 2023 Dec 13.

Functional gallbladder disorder: Interim analysis of a prospective cohort study

Kevin J Xu  1 , Josie C Brock  1 , Naeem Goussous  1 , Anne M Sill  1 , Steven C Cunningham  2
Affiliations

Functional gallbladder disorder: Interim analysis of a prospective cohort study

Kevin J Xu et al. Am J Surg. 2024 Mar.

Abstract

Background: Functional gallbladder disorder (FGBD) remains a controversial indication for cholecystectomy.

Methods: A prospective cohort study enrolled patients strictly meeting Rome criteria for FGBD, and cholecystectomy was performed. They were assessed pre- and 3 and 6 months postoperatively with surveys of abdominal pain and quality of life (RAPID and SF-12 surveys, respectively). Interim analysis was performed.

Results: Although neither ejection fraction nor pain reproduction predicted success after cholecystectomy, the vast majority of enrolled patients had a successful outcome after undergoing cholecystectomy for FGBD: of a planned 100 patients, 46 were enrolled. Of 31 evaluable patients, 26 (83.9 ​%) reported RAPID improvement and 28 (93.3 ​%) SF12 improvement at 3- or 6-month follow-up.

Conclusion: FGBD, strictly diagnosed, should perhaps no longer be a controversial indication for cholecystectomy, since its success rate for biliary pain in this study was similar to that for symptomatic cholelithiasis. Larger-scale studies or randomized trials may confirm these findings.

Keywords: Biliary dyskinesia; Cholecystectomy; Functional gallbladder disorder; Gallbladder dysfunction; ROME criteria.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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