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Case Reports
. 2023 Dec 18;16(12):e257569.
doi: 10.1136/bcr-2023-257569.

Case of primary low-grade neuroendocrine carcinoma of the skin

Sara Krogh  1 , Mette Bak Nielsen  2 , Linda Skibsted Kornerup  3 , Gitte Dam  3
Affiliations
Case Reports

Case of primary low-grade neuroendocrine carcinoma of the skin

Sara Krogh et al. BMJ Case Rep. .

Abstract

A man presents a 4 mm skin tumour at his general practitioner. The tumour is removed on the suspicion of a dermatofibroma. Important differential diagnoses are sebaceous neoplasms, melanomas, Merkel cell carcinomas and large cell neuroendocrine carcinoma, and metastases of neuroendocrine neoplasms from the gut or lung. Immunohistochemical staining excluded sebaceous neoplasm, melanoma and Merkel cell carcinoma, however, was positive for multiple neuroendocrine markers. Relevant scans showed no signs of a primary tumour anywhere else. The final diagnosis was a primary low-grade neuroendocrine carcinoma of the skin. At 30 months follow-up, there was no sign of recurrence.

Keywords: Dermatology; Neuroendocrinology; Pathology.

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Conflict of interest statement

Competing interests: GD received teaching activities for Ipsen, advanced Pharma and Sam Nordic.

Figures

Figure 1
Figure 1
Histopathological features on H&E-stained slides. (A) The tumour was 4 mm with a solid pattern in the centre and more organoid pattern without necrosis in the border of the tumour (×2). (B, C) The tumour cells were uniform with oval to round nuclei with dispersed chromatin, inconspicuous nucleoli and eosinophilic and fine granular cytoplasm (×10) (×40).
Figure 2
Figure 2
Immunohistochemical staining revealed expression of (A) ISLET-1 and dot-like positive stain for pan cytokeratin (AE1/3) (×20) and (B) synaptophysin (×2) in the peripheral part of the tumour, (C) CD56 in the centre of the tumour and (D) SOX-10 (×2) and (E) S-100 (×2) in the peripheral part as well as the centre of the tumour. The Ki-67 index (×20) varied between the border (F) and the centre (G) of the tumour but was up to 10%.
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