Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Apr;476(4):533-543.
doi: 10.1007/s00424-023-02897-7. Epub 2023 Dec 19.

Pendrin: linking acid base to blood pressure

François Brazier  1 , Nicolas Cornière  1 , Nicolas Picard  2 , Régine Chambrey  3 , Dominique Eladari  4   5   6
Affiliations
Review

Pendrin: linking acid base to blood pressure

François Brazier et al. Pflugers Arch. 2024 Apr.

Abstract

Pendrin (SLC26A4) is an anion exchanger from the SLC26 transporter family which is mutated in human patients affected by Pendred syndrome, an autosomal recessive disease characterized by sensoneurinal deafness and hypothyroidism. Pendrin is also expressed in the kidney where it mediates the exchange of internal HCO3- for external Cl- at the apical surface of renal type B and non-A non-B-intercalated cells. Studies using pendrin knockout mice have first revealed that pendrin is essential for renal base excretion. However, subsequent studies have demonstrated that pendrin also controls chloride absorption by the distal nephron and that this mechanism is critical for renal NaCl balance. Furthermore, pendrin has been shown to control vascular volume and ultimately blood pressure. This review summarizes the current knowledge about how pendrin is linking renal acid-base regulation to blood pressure control.

Keywords: Acid base; Anion exchanger; Blood pressure; Chloride transport; Membrane transporter.

PubMed Disclaimer

References

    1. Alper SL, Natale J, Gluck S, Lodish HF, Brown D (1989) Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase. Proc Natl Acad Sci U S A 86:5429–5433. https://doi.org/10.1073/pnas.86.14.5429 - DOI - PubMed - PMC
    1. Berg P, Jensen T, Andersen JF, Svendsen SL, Modvig IM, Wang T, Frische S, Chow BKC, Malte H, Holst JJ, Sorensen MV, Leipziger J (2023) Loss of the secretin receptor impairs renal bicarbonate excretion and aggravates metabolic alkalosis in mice during acute base-loading. J Am Soc Nephrol 34:1329–1342. https://doi.org/10.1681/ASN.0000000000000173 - DOI - PubMed
    1. Berg P, Sorensen MV, Rousing AQ, Vebert Olesen H, Jensen-Fangel S, Jeppesen M, Leipziger J (2022) Challenged urine bicarbonate excretion as a measure of cystic fibrosis transmembrane conductance regulator function in cystic fibrosis. Ann Intern Med 175:1543–1551. https://doi.org/10.7326/M22-1741 - DOI - PubMed
    1. Berg P, Svendsen SL, Hoang TTL, Praetorius HA, Sorensen MV, Leipziger J (2021) Impaired renal HCO(3)(-) secretion in CFTR deficient mice causes metabolic alkalosis during chronic base-loading. Acta Physiol (Oxford) 231:e13591. https://doi.org/10.1111/apha.13591 - DOI
    1. Berg P, Svendsen SL, Sorensen MV, Larsen CK, Andersen JF, Jensen-Fangel S, Jeppesen M, Schreiber R, Cabrita I, Kunzelmann K, Leipziger J (2020) Impaired renal HCO(3)(-) excretion in cystic fibrosis. J Am Soc Nephrol 31:1711–1727. https://doi.org/10.1681/ASN.2020010053 - DOI - PubMed - PMC

LinkOut - more resources