Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Nov 18;15(11):e48991.
doi: 10.7759/cureus.48991. eCollection 2023 Nov.

Pierre-Marie Bamberger Syndrome Leading to the Diagnosis and Surgical Treatment of a Localized Lung Cancer

Evangelos Koliakos  1 , Dimitri Chappalley  2 , Evangelos Kalogiannis  3 , Sebastien Sgardello  4 , Michel Christodoulou  1
Affiliations
Case Reports

Pierre-Marie Bamberger Syndrome Leading to the Diagnosis and Surgical Treatment of a Localized Lung Cancer

Evangelos Koliakos et al. Cureus. .

Abstract

Hypertrophic osteoarthropathy (HOA), manifested with digital clubbing, tubular bone periostosis, and large joint synovial effusions, exists in two forms: primary, which is the rarest form, and secondary. The latter is frequently associated with lung diseases and, in some cases, with non-small cell lung cancer (NSCLC) and is thus expressed in the form of a paraneoplastic syndrome. We report the case of a male smoker who was presented with secondary hypertrophic osteoarthropathy and was subsequently diagnosed with primary adenocarcinoma of the lung. A 63-year-old male with a history of ischemic heart disease and heavy tobacco consumption (60 pack-years) presented with painful osteoarthritis of all four extremities. A chest computed tomography (CT), a positron emission tomography (PET) scan, and a bronchoscopy revealed a 9 cm mass within the right lower lobe without mediastinal adenopathy. Bilateral lower limb X-rays revealed osteoarthropathy of the tibia. A right lower lobectomy and mediastinal lymph node dissection were performed. Final histopathology analysis reported an advanced mixed pulmonary adenocarcinoma. The postoperative course was uneventful and the patient was discharged on postoperative day 6. This report has highlighted the importance of clinical awareness of the association between HOA and carcinoma of the lung.

Keywords: cyclooxygenase 2; lung neoplasms; non-small-cell lung carcinoma; osteoarthropathy; vascular endothelial growth factors.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Clinical osteoarticular manifestations of Pierre-Marie Bamberger syndrome
Preoperative photograph of the patient's hands demonstrating typical bilateral digital clubbing
Figure 2
Figure 2. Chest CT scan
Chest CT demonstrating a 9-centimeter pulmonary mass located in the right lower lobe (red arrow)
Figure 3
Figure 3. Preoperative PET-CT scan
Demonstration of high fluorodeoxyglucose (FDG) uptake in the mass of the right lower lobe (left arrow) associated with ipsilateral hilar adenopathy (right arrow)
Figure 4
Figure 4. Radiological osteoarticular manifestations of the Pierre-Marie Bamberger syndrome
X-ray of the left ankle in five-month intervals demonstrating the appearance of hypertrophic osteoarthropathy (arrows) and periostosis of the tibia and fibula
See this image and copyright information in PMC

References

    1. Hypertrophic osteoarthropathy: what a rheumatologist should know about this uncommon condition. Pineda C, Martínez-Lavín M. https://pubmed.ncbi.nlm.nih.gov/23597970/ Rheum Dis Clin North Am. 2013;39:383–400. - PubMed
    1. Chakraborty RK, Sharma S. Treasure Island (FL): StatPearls [Internet]; 2022. Secondary Hypertrophic Osteoarthropathy. - PubMed
    1. Hypertrophic osteoarthropathy. Martínez-Lavín M. https://pubmed.ncbi.nlm.nih.gov/32291203/ Best Pract Res Clin Rheumatol. 2020;34:101507. - PubMed
    1. Periostitis and hypertrophic pulmonary osteoarthropathy: report of 2 cases and review of the literature. Yao Q, Altman RD, Brahn E. https://pubmed.ncbi.nlm.nih.gov/18760449/ Semin Arthritis Rheum. 2009;38:458–466. - PubMed
    1. Hypertrophic pulmonary osteoarthropathy as a paraneoplastic manifestation of lung cancer. Ito T, Goto K, Yoh K, et al. https://pubmed.ncbi.nlm.nih.gov/20453688/ J Thorac Oncol. 2010;5:976–980. - PubMed

Publication types

LinkOut - more resources