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. 2024 Apr 1;52(2):47-53.
doi: 10.1249/JES.0000000000000331. Epub 2023 Dec 17.

Low Response to Aerobic Training in Metabolic Disease: Role of Skeletal Muscle

Rogerio Nogueira Soares, Sarah J Lessard

Low Response to Aerobic Training in Metabolic Disease: Role of Skeletal Muscle

Rogerio Nogueira Soares et al. Exerc Sport Sci Rev. .

Abstract

Aerobic exercise is established to increase cardiorespiratory fitness (CRF), which is linked to reduced morbidity and mortality. However, people with metabolic diseases such as type 1 and type 2 diabetes may be more likely to display blunted improvements in CRF with training. Here, we present evidence supporting the hypothesis that altered skeletal muscle signaling and remodeling may contribute to low CRF with metabolic disease.

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Conflict of interest statement

Conflict of interest: The authors have no conflict of interest.

Figures

Figure.
Figure.. Mechanisms associated with blunted improvements in CRF in people with metabolic disease.
Systemic factors that accompany metabolic disease, such as chronic hyperglycemia and insulin resistance are associated with blunted improvements in CRF with aerobic training. In skeletal muscle, ECM accumulation is associated with impaired aerobic remodeling, including lower muscle blood flow and capillary density, a less oxidative muscle fiber type, and impaired mitochondrial function. At the molecular level, altered signal transduction with exercise and altered gene expression likely contribute to the impaired adaptive response to training. Figure was created with Biorender.com.
See this image and copyright information in PMC

References

    1. Blair SN, Kampert JB, Kohl HW 3rd, Barlow CE, Macera CA, Paffenbarger RS Jr., et al. Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA. 1996;276(3):205–10. - PubMed
    1. Church TS, Cheng YJ, Earnest CP, Barlow CE, Gibbons LW, Priest EL, et al. Exercise capacity and body composition as predictors of mortality among men with diabetes. Diabetes Care. 2004;27(1):83–8. - PubMed
    1. Wickramasinghe CD, Ayers CR, Das S, de Lemos JA, Willis BL, Berry JD. Prediction of 30-year risk for cardiovascular mortality by fitness and risk factor levels: the Cooper Center Longitudinal Study. Circ Cardiovasc Qual Outcomes. 2014;7(4):597–602. - PMC - PubMed
    1. Grundy SM, Barlow CE, Farrell SW, Vega GL, Haskell WL. Cardiorespiratory fitness and metabolic risk. Am J Cardiol. 2012;109(7):988–93. - PubMed
    1. Ekelund LG, Haskell WL, Johnson JL, Whaley FS, Criqui MH, Sheps DS. Physical fitness as a predictor of cardiovascular mortality in asymptomatic North American men. The Lipid Research Clinics Mortality Follow-up Study. N Engl J Med. 1988;319(21):1379–84. - PubMed

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