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Observational Study
. 2024 Jun;17(3):554-557.
doi: 10.1007/s12265-023-10455-w. Epub 2023 Dec 19.

Absence of Myocardial Involvement After SARS-CoV-2 Vaccination in Asymptomatic Adolescents

Rocío Párraga  1   2 , Carlos Real  1   2 , Inés García-Lunar  1   3   4 , Gonzalo Pizarro  1   4   5 , Javier Sánchez-González  6 , Raquel Diaz-Munoz  7 , Ernesto González-Calvo  1   2 , Juan Miguel Fernandez-Alvira  1 , Jesús Martínez-Gómez  1 , Rodrigo Fernández-Jiménez  8   9   10
Affiliations
Observational Study

Absence of Myocardial Involvement After SARS-CoV-2 Vaccination in Asymptomatic Adolescents

Rocío Párraga et al. J Cardiovasc Transl Res. 2024 Jun.

Abstract

This study aimed to evaluate the presence of subclinical myocardial damage in adolescents who were vaccinated against SARS-CoV-2. One hundred twenty asymptomatic adolescents with a mean age of 16.0 ± 0.4 years (51% girls) underwent cardiac magnetic resonance (CMR) imaging. SARS-CoV-2 IgG/IgM antibody testing was performed, and self-reported dates of confirmed SARS-CoV-2 infection and/or vaccination were collected. Participants were classified according to SARS-CoV-2 status as naïve (non-infected and unvaccinated, n = 74), infected (unvaccinated, n = 23), and vaccinated (independently of past infection status, n = 23). Biventricular volumes and ejection fraction and myocardial T2 relaxation time were similar in the three groups. T1 relaxation time was slightly higher in vaccinated adolescents (1249 ± 35 ms) than in naïve and infected participants (1231 ± 30 ms and 1227 ± 29 ms, respectively; p = 0.035), although this difference was considered clinically irrelevant. This observational study found no evidence of relevant subclinical myocardial involvement after SARS-CoV-2 vaccination in asymptomatic adolescents.

Keywords: Adolescents; Cardiovascular magnetic resonance; Myocarditis; SARS-CoV-2.

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References

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