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. 2023 Dec;27(6 Suppl):57-63.
doi: 10.26355/eurrev_202312_34690.

Autoantibodies detection in patients affected by autoimmune retinopathies

M R Ceccarini  1 , M C Medori, K Dhuli, S Tezzele, G Bonetti, C Micheletti, P E Maltese, S Cecchin, K Donato, L Colombo, L Rossetti, G Staurenghi, A P Salvetti, M Oldani, L Ziccardi, D Marangoni, G Iarossi, B Falsini, G Placidi, F D'Esposito, F Viola, M Nassisi, G Leone, L Cimino, L De Simone, V Mastrofilippo, T Beccari, M Bertelli
Affiliations

Autoantibodies detection in patients affected by autoimmune retinopathies

M R Ceccarini et al. Eur Rev Med Pharmacol Sci. 2023 Dec.

Retraction in

  • Retraction Note: Autoantibodies detection in patients affected by autoimmune retinopathies.
    Ceccarini MR, Medori MC, Dhuli K, Tezzele S, Bonetti G, Micheletti C, Maltese PE, Cecchin S, Donato K, Colombo L, Rossetti L, Staurenghi G, Salvetti AP, Oldani M, Ziccardi L, Marangoni D, Iarossi G, Falsini B, Placidi G, D'Esposito F, Viola F, Nassisi M, Leone G, Cimino L, De Simone L, Mastrofilippo V, Beccari T, Bertelli M. Ceccarini MR, et al. Eur Rev Med Pharmacol Sci. 2024 May;28(9):3293. doi: 10.26355/eurrev_202405_36203. Eur Rev Med Pharmacol Sci. 2024. PMID: 38766784

Expression of concern in

  • Expression of Concern.
    Listed NA. Listed NA. Eur Rev Med Pharmacol Sci. 2024 Jan;28(2):445. doi: 10.26355/eurrev_202401_35160. Eur Rev Med Pharmacol Sci. 2024. PMID: 38305629

Abstract

Objective: Autoimmune retinopathies (ARs) encompass a spectrum of immune diseases that are characterized by the presence of autoantibodies against retinal proteins in the bloodstream. These autoantibodies (AAbs) lead to a progressive and sometimes rapid loss of vision. ARs commonly affect subjects over 50 years of age, but also rare cases of kids under 3 years of age have been reported.

Patients and methods: In this study, 47 unrelated Caucasian patients were enrolled. All subjects showed negative cancer diagnoses and negative results in their genetic screenings. We studied 8 confirmed retinal antigens using Western blotting analysis, with α-enolase followed by carbonic anhydrase II being the two most frequently found in the patients' sera.

Results: Nineteen patients were positive (40.4%), thirteen uncertain (27.7%), and fifteen were negative (31.9%). Their gender did not correlate with the presence of AAbs (p=0.409).

Conclusions: AAbs are responsible for retinal degeneration in some cases, while in others, they contribute to exacerbating the progression of the disease; however, their detection is crucial to reaching a better diagnosis and developing more effective treatments for these conditions. Moreover, finding good biomarkers is important not only for AR monitoring and prognosis, but also for helping with early cancer diagnosis.

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