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Comment
. 2024 Mar 1;30(5):934-936.
doi: 10.1158/1078-0432.CCR-23-3138.

Therapeutic Hope on the Surface of Ewing Sarcoma

Kelly M Bailey  1
Affiliations
Comment

Therapeutic Hope on the Surface of Ewing Sarcoma

Kelly M Bailey. Clin Cancer Res. .

Abstract

A detailed analysis of the Ewing sarcoma surfacesome has arrived. Robust expression of surface CDH11 and ENPP1 was identified. This "comprehensive catalog" of the Ewing surfacesome serves as a fresh roadmap to development of new therapeutic approaches, including immunotherapies and multi-modality therapeutic combinations, to target aggressive Ewing tumor subpopulations. See related article by Mooney et al., p. 1022.

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Conflict of interest statement

Conflicts of Interest

The authors declare no potential conflicts of interest.

Figures

Figure 1.
Figure 1.. ENPP1 cell surface expression in Ewing sarcoma: better understanding surface expression heterogeneity and persistence.
Continued preclinical development of ENPP1 could include better defining baseline intra-tumoral expression heterogeneity, evolution of expression upon disease progression, and understanding the impact of other anti-cancer agents on ENPP1 expression.
See this image and copyright information in PMC

Comment on

References

    1. Mooney B, Negri GL, Shyp T, Delaidelli A, Zhang H-F, Spencer Miko SE, et al. Surface and global proteome analysis identify ENPP1 and other surface proteins as actionable immunotherapeutic targets in Ewing sarcoma. Clin Cancer Res 2023. - PMC - PubMed
    1. Zhang H-F, Hughes CS, Li W, He J-Z, Surdez D, El-Nagger AM et al. Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma. Cancer Discov. 2021. Nov; 11(11):2884–2903. - PMC - PubMed
    1. Franzetti G-A, Laud-Duval K, van der Ent W, Brisac A, Irondelle M, Aubert S, et al. Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells. Oncogene. 2017. June 22;36(25):3505–3514. - PMC - PubMed
    1. Shulman DS, Chen S, Hall D, Nag A, Thorner AR, Lessnick SL et al. Adverse prognostic impact of the loss of STAG2 protein expression in patients with newly diagnosed localised Ewing sarcoma: A report from the Children’s Oncology Group. Br J Cancer. 2022. Dec; 127(12):2220–2226. - PMC - PubMed
    1. Zhang Y, Shang C, Wang N, An G, Zhang E, Lin Q, et al. Abstract LB214: A first-in-class bispecific antibody-drug conjugate (DM002) targeting HER3 and the juxtamembrane domain of MUC1. Cancer Res (2023) 83 (8_Supplement): LB214.

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