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. 2024 Mar 29;346(S2):15-19.
doi: 10.5802/crbiol.130.

François Gros: from antibiotics to messenger RNA

Moshe Yaniv
Free article

François Gros: from antibiotics to messenger RNA

Moshe Yaniv. C R Biol. .
Free article

Abstract
in English, French

François Gros was a prominent French Molecular Biologist who made a major contribution to the discovery of messenger RNA in 1961. He pursued outstanding research on bacterial mRNA and its translation into proteins followed by pioneering work on muscle differentiation. I was lucky to be among his graduate students and owe much of my success in science to him. In this short text I will describe how the initial post-war studies of François guided him to discover the existence of short-lived RNA in bacteria, the messenger RNA containing the information for protein synthesis. I will also recount the influence he had on his students and their carrier in science.

François Gros était un éminent biologiste moléculaire français qui a contribué de manière décisive à la découverte de l’ARN messager en 1961. Il a poursuivi des recherches remarquables sur l’ARNm bactérien et sa traduction en protéines, suivies de travaux pionniers sur la différenciation musculaire. J’ai eu la chance d’être l’un de ses étudiants de thèse d’État et je lui dois une grande partie de ma réussite scientifique. Dans ce court texte, je décrirai comment les études initiales d’après-guerre de François l’ont amené à découvrir l’existence d’un ARN à courte durée de vie dans les bactéries, l’ARN messager, qui contient l’information nécessaire à la synthèse des protéines. Je raconterai également l’influence qu’il a eue sur ses étudiants et leur carrière scientifique.

Keywords: François Gros; messenger RNA; myogenesis; translation.

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