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Review
. 2023 Dec 5:14:1297506.
doi: 10.3389/fimmu.2023.1297506. eCollection 2023.

Biology of endophilin and it's role in disease

Lu-Qi Yang  1 , An-Fang Huang  2 , Wang-Dong Xu  1
Affiliations
Review

Biology of endophilin and it's role in disease

Lu-Qi Yang et al. Front Immunol. .

Abstract

Endophilin is an evolutionarily conserved family of protein that involves in a range of intracellular membrane dynamics. This family consists of five isoforms, which are distributed in various tissues. Recent studies have shown that Endophilin regulates diseases pathogenesis, including neurodegenerative diseases, tumors, cardiovascular diseases, and autoimmune diseases. In vivo, it regulates different biological functions such as vesicle endocytosis, mitochondrial morphological changes, apoptosis and autophagosome formation. Functional studies confirmed the role of Endophilin in development and progression of these diseases. In this study, we have comprehensively discussed the complex function of Endophilin and how the family contributes to diseases development. It is hoped that this study will provide new ideas for targeting Endophilin in diseases.

Keywords: autophagy; diseases; endocytosis; endophilin; function.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Signalings of Endophilin A. Endophilin A binds to synaptic proteins and dynamin proteins through the SH3 structural domain, and is necessary for membrane rupture and vesicle release. Endophilin A2 overexpression promotes interaction of Bif-1 with Beclin-1. This process will promote formation of autophagosomes, thereby promoting autophagy.
Figure 2
Figure 2
Signalings of Endophilin B. Endophilin B1 forms a complex with Beclin-1 through UVRAG and activates PI3KC3, thus inducing autophagy. Bif-1 interacts with Bax to promote release of cytochrome C in the mitochondria, activating the apoptosis-related signaling pathways.
See this image and copyright information in PMC

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