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Review
. 2024 Apr 1;32(2):125-133.
doi: 10.1097/MOO.0000000000000952. Epub 2023 Nov 30.

Management of aggressive variants of papillary thyroid cancer

Ying Ki Lee  1 , Aleix Rovira  1 , Paul V Carroll  2 , Ricard Simo  1
Affiliations
Review

Management of aggressive variants of papillary thyroid cancer

Ying Ki Lee et al. Curr Opin Otolaryngol Head Neck Surg. .

Abstract

Purpose of review: The aim of this study was to provide a timely and relevant review of the latest findings and explore appropriate management of aggressive variants of papillary thyroid cancer (AVPTC).

Recent findings: In general, AVPTCs tend to exhibit more invasive characteristics, a lack of responsiveness to radioiodine, increased occurrences of regional spreading, distant metastases and higher mortality rates. Meanwhile, each variant showcases unique clinical and molecular profiles.

Summary: Given the elevated risk of recurrence postsurgery, a more aggressive strategy may be necessary when suspected preoperatively, particularly for those presenting with invasive features. Decision on the extent of surgical treatment and adjuvant therapy is individualized and made by experienced clinicians and multidisciplinary teams based on the clinical presentation, presence of aggressive features and molecular profile. Future studies on development of personalized medicine and molecular target therapy may offer tailored treatment options.

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References

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