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. 2023 Dec 20;23(11):e2787.
doi: 10.5867/medwave.2023.11.2787.

SARS-CoV-2 humoral immune response in patients with cardiovascular risk factors: The COmmunity Cohort Study

[Article in English, Spanish]
Vivienne C Bachelet  1 , Ignacio Silva-Ayarza  1 , María S Navarrete  1
Affiliations

SARS-CoV-2 humoral immune response in patients with cardiovascular risk factors: The COmmunity Cohort Study

[Article in English, Spanish]
Vivienne C Bachelet et al. Medwave. .

Abstract
in English, Spanish

Based on the recommendations of the Vaccine Advisory Committee and the National Immunization Program, Chile implemented an early vaccination process of the population with vaccines from different laboratories. The study of neutralizing antibody levels in different population subgroups contributes to the establishment of correlates of protection against SARS-CoV-2 infection. In 2022 and 2023 we set up a community cohort of 914 adults with cardiovascular risk factors. In this cohort we are measuring the humoral immune response to exposure to SARS-CoV-2 antigens, either by vaccines or infection, as well as the incidence of COVID-19 and other adverse events. This cohort, which we call The COmmunity Cohort, is providing us with valuable information on the levels of neutralizing antibodies in these individuals and their degree of protection against COVID-19.

A partir de las recomendaciones emanadas del Comité Asesor en Vacunas y el Programa Nacional de Inmunizaciones, Chile implementó precozmente un proceso de vacunación de la población con vacunas provenientes de diferentes laboratorios. El estudio de los niveles de anticuerpos neutralizantes en diferentes subgrupos poblacionales, contribuye al establecimiento de los correlatos de protección frente a infección por SARS-CoV-2. En 2022 y 2023 establecimos una cohorte comunitaria de 914 adultos con factores de riesgo cardiovascular. En esta cohorte estamos midiendo la respuesta inmune humoral frente a exposición a antígenos de SARS-CoV-2, ya sea por vacunas o por infección, así como la incidencia de COVID-19 y otros eventos adversos. Esta cohorte, que llamamos, nos está entregando valiosa información sobre los niveles de anticuerpos neutralizantes en estas personas y su grado de protección frente al COVID-19.

Keywords: COVID-19; Cohort studies; SARS-CoV-2; vaccines.

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Conflict of interest statement

The authors declare that they have no conflicts of interest with the subject matter of this article.

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