Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Feb:123:102672.
doi: 10.1016/j.ctrv.2023.102672. Epub 2023 Dec 14.

Breaking barriers in triple negative breast cancer (TNBC) - Unleashing the power of antibody-drug conjugates (ADCs)

Arianna Dri  1 , Grazia Arpino  2 , Giampaolo Bianchini  3 , Giuseppe Curigliano  4 , Romano Danesi  5 , Michelino De Laurentiis  6 , Lucia Del Mastro  7 , Alessandra Fabi  8 , Daniele Generali  9 , Alessandra Gennari  10 , Valentina Guarneri  11 , Daniele Santini  12 , Edda Simoncini  13 , Claudio Zamagni  14 , Fabio Puglisi  15
Affiliations
Free article
Review

Breaking barriers in triple negative breast cancer (TNBC) - Unleashing the power of antibody-drug conjugates (ADCs)

Arianna Dri et al. Cancer Treat Rev. 2024 Feb.
Free article

Erratum in

Abstract

Antibody-drug conjugates (ADCs) represent a novel class of molecules composed of a recombinant monoclonal antibody targeted to a specific cell surface antigen, conjugated to a cytotoxic agent through a cleavable or non-cleavable synthetic linker. The rationale behind the development of ADCs is to overcome the limitations of conventional chemotherapy, such as the narrow therapeutic window and the emergence of resistance mechanisms. ADCs had already revolutionized the treatment algorithm of HER2-positive breast cancer. Currently, emergent non-HER2 targeted ADCs are gaining momentum, with special focus on triple-negative disease therapeutic landscape. Sacituzumab govitecan (SG) is an ADC consisting of a humanized monoclonal antibody hRS7 targeting trophoblast cell surface antigen 2 (Trop2), linked to the topoisomerase I inhibitor SN-38 by a hydrolysable linker. It currently stands as the only non-HER2 targeted ADC that already received approval for the treatment of unresectable locally advanced or metastatic triple negative breast cancer (TNBC) in patients who had received two or more prior systemic therapies, with at least one for advanced disease. The purpose of these review is to analyze the available evidence regarding ADCs in TNBC, alongside with providing an overview on the ongoing and future research horizons in this field.

Keywords: Antibody-drug conjugates; Breast cancer; Sacituzumab govitecan; Triple negative breast cancer.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest A.D. Has no conflict of interest to declare. G.A. Research and medical writing: AstraZeneca; advisory boards, travel grants, activities as a speaker, consultancy: AstraZeneca, Daiichi Sankyo, Eisai, Eli Lilly, Gilead, Exact Science, Novartis, Roche, Seagen, Viatris. G.B. Advisory boards, travel grants, consultancy: Seagen, Eli Lilly, Novartis, Pfizer, Roche, AstraZeneca, MSD, Daiichi Sankyio, Eisai, Gilead, Exact Science, Stemline, Agendia. G.C. Advisory boards, activities as a speaker, travel grants, research grants: AstraZeneca, Daichii Sankyo, Lilly, Gilead, MSD, Novartis, Exact Sciences, Menarini, Pfizer, Roche, Seagen. R.D: Advisory boards, activities as a speaker, manuscript writing, travel grants, consultancy: Eisai, GSK, Novartis, AstraZeneca, Eli Lilly, Sanofi, SERB, Roche, Takeda, Pfizer. M.D.L. Advisory boards, activities as a speaker, travel grants, consultancy: Eli Lilly, Novartis, Seagen, Takeda, Roche, Daiichi Sankyo, Tomalab, Gilead, Genetic, Menarini, Sophos, AstraZeneca, Pfizer, Sanofi, Ipsen, Pierre Fabre, GSK. L.D.M. Research grants: Eli Lilly, Novartis, Roche, Daiichi Sankyo, Seagen, AstraZeneca, Gilead, Pierre Fabre; advisory boards, activities as a speaker, travel grants, consultancy: Roche, Novartis, Pfizer, Eli Lilly, Daiichi Sankyo, AstraZeneca, MSD, Seagen, Gilead, Pierre Fabre, Eisai, Exact Sciences, Ipsen, GSK, Agendia, Stemline. A.F. Advisory boards: Roche, Novartis, Eli Lilly, Pfizer, MSD, Pierre Fabre, Eisai, Gilead, Seagen, Astra Zeneca, Exact Sciences; consulting fees: Dompé Farmaceutici S.p.A. D.G. Research funding: Menarini, Seagen, Novartis, AstraZeneca; advisory boards, activities as a speaker, consultancy: Seagen, Novartis, Eli Lilly, Roche, Gilead, Pfizer, Eisai, Exact Sciences. A.G. Research grants: Pharmanutra, AAA; advisory boards, activities as a speaker, travel grants, consultancy: Roche, Novartis, Pfizer, Eli Lilly, Daiichi Sankyo, AstraZeneca, MSD, Seagen, Gilead, Pierre Fabre, Eisai, Exact Sciences, Stemline. V.G. Advisory board: AstraZeneca, Daiichi Sankyo, Eisai, Eli Lilly, Exact Sciences, Gilead, Merck Serono, MSD, Novartis, Pfizer, Olema Oncology; activites as a speaker: AstraZeneca, Daiichi Sankyo, Eli Lilly, Exact Sciences, Gilead, GSK, Novartis; expert testimony: Eli Lilly. D.S. Advisory boards: Janssen, EISAI, Roche, Astellas, Daiichi Sankyo, MSD, Merck, Pfizer, Eli Lilly, Novartis, Ipsen, Bayer, Incyte, Gilead. E.S. Advisory boards, activities as a speaker, travel grants: Seagen, Pfizer, Exact Sciences, Daiichi Sankyo, MSD, Gilead, Lilly. C.Z. Research fundings: Roche, Novartis, AstraZeneca, Pfizer, Seattle Genetics, Tesaro, Pierre Fabre, Istituto Gentili, Takeda, TEVA, Medivation, AbbVie, Array BioPharma, Morphotek, Synthon, Daiichi Sankyo, MSD, GSK, Gilead; advisory boards and travel grants: Roche, Eisai, Novartis, AstraZeneca, Pfizer, PharmaMar, Amgen, Tesaro, Quintiles IMS, Pierre Fabre, Istituto Gentili, Eli Lilly, Celgene, Daiichi Sankyo, Exact Sciences, MSD, GSK, Gilead. F.P. Advisory boards, activities as a speaker, travel grants, research grants: AstraZeneca, Daiichi Sankyo, Eisai, Lilly, Gilead, MSD, Novartis, Exact Sciences, Menarini, Pierre Fabre, Pfizer, Roche, Seagen; research funding: AstraZeneca, Eisai, Roche. Funding declaration: This editorial project received financial support thorugh an unconditional grant from Gilead. The funding source had no involvement in the project's design, data collection, analysis, data interpretation, article writing, or the decision to submit it for publication.

MeSH terms