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. 2023 Oct;180 Suppl 2(Suppl 2):S145-S222.
doi: 10.1111/bph.16178.

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

Stephen P H Alexander  1 , Alistair A Mathie  2 , John A Peters  3 , Emma L Veale  4 , Jörg Striessnig  5 , Eamonn Kelly  6 , Jane F Armstrong  7 , Elena Faccenda  7 , Simon D Harding  7 , Jamie A Davies  7 , Richard W Aldrich  8 , Bernard Attali  9 , Austin M Baggetta  10 , Elvir Becirovic  11 , Martin Biel  11 , Roslyn M Bill  12 , Ana I Caceres  13 , William A Catterall  14 , Alex C Conner  15 , Paul Davies  16 , Katrien De Clerq  17 , Markus Delling  18 , Francesco Di Virgilio  19 , Simonetta Falzoni  19 , Stefanie Fenske  11 , Anna Fortuny-Gomez  20 , Samuel Fountain  20 , Chandy George  21 , Steve A N Goldstein  22 , Christian Grimm  11 , Stephan Grissmer  23 , Kotdaji Ha  18 , Verena Hammelmann  11 , Israel Hanukoglu  24 , Meiqin Hu  25 , Ad P Ijzerman  26 , Sairam V Jabba  13 , Mike Jarvis  27 , Anders A Jensen  28 , Sven E Jordt  13 , Leonard K Kaczmarek  29 , Stephan Kellenberger  30 , Charles Kennedy  31 , Brian King  32 , Philip Kitchen  12 , Qiang Liu  25 , Joseph W Lynch  33 , Jessica Meades  20 , Verena Mehlfeld  11 , Annette Nicke  11 , Stefan Offermanns  34 , Edward Perez-Reyes  35 , Leigh D Plant  10 , Lachlan Rash  36 , Dejian Ren  37 , Mootaz M Salman  38 , Werner Sieghart  39 , Lucia G Sivilotti  32 , Trevor G Smart  32 , Terrance P Snutch  40 , Jinbin Tian  41 , James S Trimmer  42 , Charlotte Van den Eynde  17 , Joris Vriens  17 , Aguan D Wei  14 , Brenda T Winn  10 , Heike Wulff  42 , Haoxing Xu  43 , Fan Yang  25 , Wei Fang  25 , Lixia Yue  44 , Xiaoli Zhang  43 , Michael Zhu  41
Affiliations

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

Stephen P H Alexander et al. Br J Pharmacol. 2023 Oct.

Abstract

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16178. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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Conflict of interest statement

Conflict of interest

The authors state that there are no conflicts of interest to disclose.

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Further reading on Acid-sensing (proton-gated) ion channels (ASICs)

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Further reading on Epithelial sodium channel (ENaC)

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Further reading on GABAA receptors

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Further reading on Glycine receptors

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Further reading on Ionotropic glutamate receptors

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Further reading on IP3 receptors

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Further reading on Nicotinic acetylcholine receptors (nACh)

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Further reading on P2X receptors

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Further reading on ZAC

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Further reading on CatSper and Two-Pore channels (TPC)

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Further reading on Cyclic nucleotide-regulated channels (CNG)

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Further reading on Calcium- and sodium-activated potassium channels (KCa, KNa)

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Further reading on Two-pore domain potassium channels (K2P)

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Further reading on Potassium channels

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Further reading on Ryanodine receptors (RyR)

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Further reading on Transient Receptor Potential channels (TRP)

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Further reading on Voltage-gated calcium channels (CaV)

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Further reading on Voltage-gated proton channel (Hv1)

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Further reading on Voltage-gated sodium channels (NaV)

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Further reading on Aquaporins

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Further reading on CFTR

    1. Fiedorczuk K et al. (2022) Mechanism of CFTR correction by type I folding correctors. Cell 185: 158–168.e11 - PubMed
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Further reading on Chloride channels

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Further reading on Connexins and Pannexins

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Further reading on Piezo channels

    1. Chesler AT et al. (2018) Portraits of a pressure sensor. Elife 7: - PMC - PubMed
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Further reading on Sodium leak channel, non-selective (NaVi)

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Further reading on Orai channels

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