The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Stephen P H Alexander¹, Arthur Christopoulos², Anthony P Davenport³, Eamonn Kelly⁴, Alistair A Mathie⁵, John A Peters⁶, Emma L Veale⁷, Jane F Armstrong⁸, Elena Faccenda⁸, Simon D Harding⁸, Jamie A Davies⁸, Maria Pia Abbracchio⁹, George Abraham³, Alexander Agoulnik¹⁰, Wayne Alexander¹¹, Khaled Al-Hosaini¹², Magnus Bäck¹³, Jillian G Baker¹, Nicholas M Barnes¹⁴, Ross Bathgate¹⁵, Jean-Martin Beaulieu¹⁶, Annette G Beck-Sickinger¹⁷, Maik Behrens¹⁸, Kenneth E Bernstein¹⁹, Bernhard Bettler²⁰, Nigel J M Birdsall²¹, Victoria Blaho²², Francois Boulay²³, Corinne Bousquet²⁴, Hans Bräuner-Osborne²⁵, Geoffrey Burnstock²⁶, Girolamo Caló²⁷, Justo P Castaño²⁸, Kevin J Catt²⁹, Stefania Ceruti⁹, Paul Chazot³⁰, Nan Chiang³¹, Bice Chini³², Jerold Chun³³, Antonia Cianciulli³⁴, Olivier Civelli³⁵, Lucie H Clapp²⁶, Réjean Couture³⁶, Helen M Cox³⁷, Zsolt Csaba³⁸, Claes Dahlgren³⁹, Gordon Dent⁴⁰, Steven D Douglas⁴¹, Pascal Dournaud³⁸, Satoru Eguchi⁴², Emanuel Escher⁴³, Edward J Filardo⁴⁴, Tung Fong⁴⁵, Marta Fumagalli⁹, Raul R Gainetdinov⁴⁶, Michael L Garelja⁴⁷, Marc de Gasparo⁴⁸, Craig Gerard³¹, Marvin Gershengorn²⁹, Fernand Gobeil⁴³, Theodore L Goodfriend⁴⁹, Cyril Goudet⁵⁰, Lukas Grätz⁵¹, Karen J Gregory², Andrew L Gundlach¹⁵, Jörg Hamann⁵², Julien Hanson⁵³, Richard L Hauger³³, Debbie L Hay⁴⁷, Akos Heinemann⁵⁴, Deron Herr⁵⁵, Morley D Hollenberg⁵⁶, Nicholas D Holliday¹, Mastgugu Horiuchi⁵⁷, Daniel Hoyer⁵⁸, László Hunyady⁵⁹, Ahsan Husain¹¹, Adriaan P IJzerman⁶⁰, Tadashi Inagami⁶¹, Kenneth A Jacobson²⁹, Robert T Jensen²⁹, Ralf Jockers³⁸, Deepa Jonnalagadda²², Sadashiva Karnik⁶², Klemens Kaupmann⁶³, Jacqueline Kemp⁶⁴, Charles Kennedy⁶⁵, Yasuyuki Kihara²², Takio Kitazawa⁶⁶, Pawel Kozielewicz⁵¹, Hans-Jürgen Kreienkamp⁶⁷, Jyrki P Kukkonen⁶⁸, Tobias Langenhan¹⁷, Dan Larhammar⁶⁹, Katie Leach², Davide Lecca⁹, John D Lee⁷⁰, Susan E Leeman⁷¹, Jérôme Leprince⁷², Xaria X Li⁷³, Stephen J Lolait⁴, Amelie Lupp⁷⁴, Robyn Macrae⁷⁵, Janet Maguire³, Davide Malfacini²⁷, Jean Mazella⁷⁶, Craig A McArdle⁴, Shlomo Melmed¹⁹, Martin C Michel⁷⁷, Laurence J Miller⁷⁸, Vincenzo Mitolo³⁴, Bernard Mouillac⁵⁰, Christa E Müller⁷⁹, Philip M Murphy⁸⁰, Jean-Louis Nahon⁷⁶, Tony Ngo²², Xavier Norel³⁸, Duuamene Nyimanu⁷⁵, Anne-Marie O'Carroll⁴, Stefan Offermanns⁸¹, Maria Antonietta Panaro³⁴, Marc Parmentier⁸², Roger G Pertwee⁸³, Jean-Philippe Pin⁸⁴, Eric R Prossnitz⁸⁵, Mark Quinn⁸⁶, Rithwik Ramachandran⁵⁶, Manisha Ray²², Rainer K Reinscheid⁷⁴, Philippe Rondard⁸⁴, G Enrico Rovati⁹, Chiara Ruzza⁸⁷, Gareth J Sanger⁸⁸, Torsten Schöneberg¹⁷, Gunnar Schulte⁵¹, Stefan Schulz⁷⁴, Deborah L Segaloff⁴⁴, Charles N Serhan³¹, Khuraijam Dhanachandra Singh⁶⁴, Craig M Smith⁸⁹, Leigh A Stoddart¹, Yukihiko Sugimoto⁹⁰, Roger Summers⁹¹, Valerie P Tan³³, David Thal⁹¹, Walter Wally Thomas⁷³, Pieter B M W M Timmermans⁹², Kalyan Tirupula⁶⁴, Lawrence Toll⁹³, Giovanni Tulipano⁹⁴, Hamiyet Unal⁹⁵, Thomas Unger⁹⁶, Celine Valant⁹¹, Patrick Vanderheyden⁸², David Vaudry⁷², Hubert Vaudry⁷², Jean-Pierre Vilardaga⁹⁷, Christopher S Walker⁹⁸, Ji Ming Wang⁹⁹, Donald T Ward¹⁰⁰, Hans-Jürgen Wester¹⁰¹, Gary B Willars¹⁰², Tom Lloyd Williams⁷⁵, Trent M Woodruff⁷³, Chengcan Yao¹⁰³, Richard D Ye¹⁰⁴

Affiliations

¹ School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
² Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, 3052, Australia.
³ Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
⁴ School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.
⁵ School of Engineering, Arts, Science and Technology, University of Suffolk, Ipswich, IP4 1QJ, UK.
⁶ Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
⁷ Medway School of Pharmacy, The Universities of Greenwich and Kent at Medway, Anson Building, Central Avenue, Chatham Maritime, Chatham, Kent, ME4 4TB, UK.
⁸ Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK.
⁹ University of Milan, Milan, Italy.
¹⁰ Florida International University, Miami, USA.
¹¹ Emory University, Atlanta, USA.
¹² King Saud University, Riyadh, Kingdom of Saudi Arabia.
¹³ Karolinska University Hospital, Stockholm, Sweden.
¹⁴ University of Birmingham, Birmingham, UK.
¹⁵ Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
¹⁶ University of Toronto, Toronto, Canada.
¹⁷ Leipzig University, Leipzig, Germany.
¹⁸ Technical University of Munich, Freising, Germany.
¹⁹ Cedars-Sinai Medical Center, Los Angeles, USA.
²⁰ University of Basel, Basel, Switzerland.
²¹ The Francis Crick Institute, London, UK.
²² Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA.
²³ University of Grenoble Alpes, Grenoble, France.
²⁴ French Institute of Health and Medical Research (INSERM), Toulouse, France.
²⁵ University of Copenhagen, Copenhagen, Denmark.
²⁶ University College London, London, UK.
²⁷ University of Padova, Padova, Italy.
²⁸ University of Córdoba, Córdoba, Spain.
²⁹ National Institute of Health, Bethesda, USA.
³⁰ Durham University, Durham, UK.
³¹ Harvard University, Boston, USA.
³² University of Milan Bicocca, Vedano al Lambro, Italy.
³³ University of California San Diego, La Jolla, USA.
³⁴ University of Bari, Bari, Italy.
³⁵ University of California Irvine, Irvine, USA.
³⁶ University of Montréal, Montréal, Canada.
³⁷ King's College London, London, UK.
³⁸ French Institute of Health and Medical Research (INSERM), Paris, France.
³⁹ University of Gothenburg, Gothenburg, Sweden.
⁴⁰ Keele University, Keele, UK.
⁴¹ University of Pennsylvania, Pennsylvania, USA.
⁴² Temple University, Philadelphia, USA.
⁴³ University of Sherbrooke, Sherbrooke, Canada.
⁴⁴ University of Iowa, Iowa City, USA.
⁴⁵ Labcorp Drug Development, Somerset, USA.
⁴⁶ Saint Petersburg State University, Saint-Petersburg, Russia.
⁴⁷ University of Otago, Dunedin, New Zealand.
⁴⁸ MG Consulting Co, Basel, Switzerland.
⁴⁹ University of Wisconsin, Madison, USA.
⁵⁰ French National Centre for Scientific Research, Montpellier, France.
⁵¹ Karolinska Institute, Stockholm, Sweden.
⁵² Amsterdam University, Amsterdam, The Netherlands.
⁵³ University of Liège, Liège, Belgium.
⁵⁴ Medical University of Graz, Graz, Austria.
⁵⁵ San Diego State University, San Diego, USA.
⁵⁶ University of Calgary, Calgary, Canada.
⁵⁷ Ehime University, Ehime, Japan.
⁵⁸ University of Melbourne, Melbourne, Australia.
⁵⁹ Semmelweis University, Budapest, Hungary.
⁶⁰ Leiden University, Leiden, The Netherlands.
⁶¹ Vanderbilt University, Nashville, USA.
⁶² Lerner Research Institute, Cleveland, USA.
⁶³ Novartis, Basel, Switzerland.
⁶⁴ Cleveland Clinic Lerner Research Institute, Cleveland, USA.
⁶⁵ Strathclyde University, Glasgow, UK.
⁶⁶ Rakuno Gakuen University, Ebetsu, Japan.
⁶⁷ University of Hamburg, Hamburg, Germany.
⁶⁸ University of Helsinki, Helsinki, Finland.
⁶⁹ Uppsala University, Uppsala, Sweden.
⁷⁰ University of Queensland, Brisbane, Australia.
⁷¹ Boston University, Boston, USA.
⁷² University of Rouen, Rouen, France.
⁷³ University of Queensland, Queensland, Australia.
⁷⁴ Friedrich Schiller University Jena, Jena, Germany.
⁷⁵ University of Cambridge, Cambridge, UK.
⁷⁶ French National Centre for Scientific Research (CNRS), Valbonne, France.
⁷⁷ Johannes Gutenberg University Mainz, Mainz, Germany.
⁷⁸ Mayo Foundation for Medical Education and Research, Scottsdale, USA.
⁷⁹ University of Bonn, Bonn, Germany.
⁸⁰ Edge Hill University, Bethesda, USA.
⁸¹ Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
⁸² Free University of Brussels, Brussels, Belgium.
⁸³ University of Aberdeen, Aberdeen, UK.
⁸⁴ University of Montpellier, Montpellier, France.
⁸⁵ University of New Mexico, Albuquerque, USA.
⁸⁶ Montana State University, Bozeman, USA.
⁸⁷ University of Ferrara, Ferrara, Italy.
⁸⁸ Queen Mary University of London, London, UK.
⁸⁹ Deakin University, Waurn Ponds, Australia.
⁹⁰ Kumamoto University, Kumamoto, Japan.
⁹¹ Monash University, Melbourne, Australia.
⁹² Kosan Biosciences Inc., San Francisco, USA.
⁹³ Florida Atlantic University, Jupiter, USA.
⁹⁴ University of Brescia, Brescia, Italy.
⁹⁵ Cleveland Clinic, Cleveland, USA.
⁹⁶ Maastricht University, Maastricht, The Netherlands.
⁹⁷ University of Pittsburgh, Pittsburgh, USA.
⁹⁸ University of Auckland, Auckland, New Zealand.
⁹⁹ National Institute of Health, Frederick, USA.
¹⁰⁰ University of Manchester, Manchester, UK.
¹⁰¹ Technical University of Munich, Munich, Germany.
¹⁰² University of Leicester, Leicester, UK.
¹⁰³ University of Edinburgh, Edinburgh, UK.
¹⁰⁴ The Chinese University of Hong Kong, Shenzhen, China.

PMID: 38123151
DOI: 10.1111/bph.16177

Free article

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Stephen P H Alexander et al. Br J Pharmacol. 2023 Oct.

Free article

. 2023 Oct:180 Suppl 2:S23-S144.

doi: 10.1111/bph.16177.

Authors

Affiliations

¹ School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
² Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, 3052, Australia.
³ Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
⁴ School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.
⁵ School of Engineering, Arts, Science and Technology, University of Suffolk, Ipswich, IP4 1QJ, UK.
⁶ Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
⁷ Medway School of Pharmacy, The Universities of Greenwich and Kent at Medway, Anson Building, Central Avenue, Chatham Maritime, Chatham, Kent, ME4 4TB, UK.
⁸ Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK.
⁹ University of Milan, Milan, Italy.
¹⁰ Florida International University, Miami, USA.
¹¹ Emory University, Atlanta, USA.
¹² King Saud University, Riyadh, Kingdom of Saudi Arabia.
¹³ Karolinska University Hospital, Stockholm, Sweden.
¹⁴ University of Birmingham, Birmingham, UK.
¹⁵ Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
¹⁶ University of Toronto, Toronto, Canada.
¹⁷ Leipzig University, Leipzig, Germany.
¹⁸ Technical University of Munich, Freising, Germany.
¹⁹ Cedars-Sinai Medical Center, Los Angeles, USA.
²⁰ University of Basel, Basel, Switzerland.
²¹ The Francis Crick Institute, London, UK.
²² Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA.
²³ University of Grenoble Alpes, Grenoble, France.
²⁴ French Institute of Health and Medical Research (INSERM), Toulouse, France.
²⁵ University of Copenhagen, Copenhagen, Denmark.
²⁶ University College London, London, UK.
²⁷ University of Padova, Padova, Italy.
²⁸ University of Córdoba, Córdoba, Spain.
²⁹ National Institute of Health, Bethesda, USA.
³⁰ Durham University, Durham, UK.
³¹ Harvard University, Boston, USA.
³² University of Milan Bicocca, Vedano al Lambro, Italy.
³³ University of California San Diego, La Jolla, USA.
³⁴ University of Bari, Bari, Italy.
³⁵ University of California Irvine, Irvine, USA.
³⁶ University of Montréal, Montréal, Canada.
³⁷ King's College London, London, UK.
³⁸ French Institute of Health and Medical Research (INSERM), Paris, France.
³⁹ University of Gothenburg, Gothenburg, Sweden.
⁴⁰ Keele University, Keele, UK.
⁴¹ University of Pennsylvania, Pennsylvania, USA.
⁴² Temple University, Philadelphia, USA.
⁴³ University of Sherbrooke, Sherbrooke, Canada.
⁴⁴ University of Iowa, Iowa City, USA.
⁴⁵ Labcorp Drug Development, Somerset, USA.
⁴⁶ Saint Petersburg State University, Saint-Petersburg, Russia.
⁴⁷ University of Otago, Dunedin, New Zealand.
⁴⁸ MG Consulting Co, Basel, Switzerland.
⁴⁹ University of Wisconsin, Madison, USA.
⁵⁰ French National Centre for Scientific Research, Montpellier, France.
⁵¹ Karolinska Institute, Stockholm, Sweden.
⁵² Amsterdam University, Amsterdam, The Netherlands.
⁵³ University of Liège, Liège, Belgium.
⁵⁴ Medical University of Graz, Graz, Austria.
⁵⁵ San Diego State University, San Diego, USA.
⁵⁶ University of Calgary, Calgary, Canada.
⁵⁷ Ehime University, Ehime, Japan.
⁵⁸ University of Melbourne, Melbourne, Australia.
⁵⁹ Semmelweis University, Budapest, Hungary.
⁶⁰ Leiden University, Leiden, The Netherlands.
⁶¹ Vanderbilt University, Nashville, USA.
⁶² Lerner Research Institute, Cleveland, USA.
⁶³ Novartis, Basel, Switzerland.
⁶⁴ Cleveland Clinic Lerner Research Institute, Cleveland, USA.
⁶⁵ Strathclyde University, Glasgow, UK.
⁶⁶ Rakuno Gakuen University, Ebetsu, Japan.
⁶⁷ University of Hamburg, Hamburg, Germany.
⁶⁸ University of Helsinki, Helsinki, Finland.
⁶⁹ Uppsala University, Uppsala, Sweden.
⁷⁰ University of Queensland, Brisbane, Australia.
⁷¹ Boston University, Boston, USA.
⁷² University of Rouen, Rouen, France.
⁷³ University of Queensland, Queensland, Australia.
⁷⁴ Friedrich Schiller University Jena, Jena, Germany.
⁷⁵ University of Cambridge, Cambridge, UK.
⁷⁶ French National Centre for Scientific Research (CNRS), Valbonne, France.
⁷⁷ Johannes Gutenberg University Mainz, Mainz, Germany.
⁷⁸ Mayo Foundation for Medical Education and Research, Scottsdale, USA.
⁷⁹ University of Bonn, Bonn, Germany.
⁸⁰ Edge Hill University, Bethesda, USA.
⁸¹ Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
⁸² Free University of Brussels, Brussels, Belgium.
⁸³ University of Aberdeen, Aberdeen, UK.
⁸⁴ University of Montpellier, Montpellier, France.
⁸⁵ University of New Mexico, Albuquerque, USA.
⁸⁶ Montana State University, Bozeman, USA.
⁸⁷ University of Ferrara, Ferrara, Italy.
⁸⁸ Queen Mary University of London, London, UK.
⁸⁹ Deakin University, Waurn Ponds, Australia.
⁹⁰ Kumamoto University, Kumamoto, Japan.
⁹¹ Monash University, Melbourne, Australia.
⁹² Kosan Biosciences Inc., San Francisco, USA.
⁹³ Florida Atlantic University, Jupiter, USA.
⁹⁴ University of Brescia, Brescia, Italy.
⁹⁵ Cleveland Clinic, Cleveland, USA.
⁹⁶ Maastricht University, Maastricht, The Netherlands.
⁹⁷ University of Pittsburgh, Pittsburgh, USA.
⁹⁸ University of Auckland, Auckland, New Zealand.
⁹⁹ National Institute of Health, Frederick, USA.
¹⁰⁰ University of Manchester, Manchester, UK.
¹⁰¹ Technical University of Munich, Munich, Germany.
¹⁰² University of Leicester, Leicester, UK.
¹⁰³ University of Edinburgh, Edinburgh, UK.
¹⁰⁴ The Chinese University of Hong Kong, Shenzhen, China.

PMID: 38123151
DOI: 10.1111/bph.16177

Abstract

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

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