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Case Reports
. 2023 Mar;35(1):67-69.
doi: 10.4314/mmj.v35i1.10.

A woman with focal neurological deficit following treatment for cholera

Johnstone J Kumwenda  1 , Arthur Daire  1 , Olive Mkwinda  2 , Noel Nazombe  3 , Atupele Mwale  3 , Glory Makhumba  3 , Samantha Musasa  1 , Fumbani Limani  1
Affiliations
Case Reports

A woman with focal neurological deficit following treatment for cholera

Johnstone J Kumwenda et al. Malawi Med J. 2023 Mar.

Abstract

A 41-year old woman was treated for cholera at one of the health centers in Blantyre. Two days after discharge from the treatment unit, she developed weakness of all 4 limbs and difficulties with speech. She was referred to the Queen Elizabeth Central Hospital. A CT scan of the brain showed hypodense lesions in the pons. A diagnosis of central pontine myelinolysis was made. She recovered slowly and was discharged from hospital 17 days after admission.

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Figures

None
Two images from the patient showing hypodense pons suggestive of myelinolysis: Blue arrows Note: CT assessment of the skull base can be difficult due to beam hardening artifact from surrounding bones. And if available, MRI is preferred.
See this image and copyright information in PMC

References

    1. Danyalian A, Heller D. Central Pontine Myelinolysis. 2019. https://www.ncbi.nlm.nih.gov/books/NBK551697/ - PubMed
    1. Adrogué H, Madias N. Hyponatremia. N Engl J Med. 2000;342:1581–1589. 10.1056. - PubMed
    1. Arieff A, Llach F, Massry S. Neurological manifestations and morbidity of hyponatremia, correlation with brain water and electrolytes. Medicine (Baltimore) 1976 Mar;55(2):121–129. - PubMed
    1. Adam R, Victor M, Mangall E. Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients. AMA Archives of Neurology and Psychiatry. 1959 Feb 1;81(2):154–172. - PubMed
    1. Morard I, Gasche Y, Kneteman M, et al. Identifying risk factors for central pontine and extrapontine myelinolysis after liver transplantation: a case-control study. Neurocrit Care. 2014 Apr;20(2):287–295. - PubMed

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