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Observational Study
. 2023 Dec 18;70(1):e20230472.
doi: 10.1590/1806-9282.20230472. eCollection 2023.

Morbimortality and determinants of reperfusion in ischemic stroke

Adriana Ribeiro Oliveira  1 , Pedro Antônio Pereira de Jesus  2 , Fábio Vieira de Bulhões  1 , Eduardo Martins Netto  1 , Jamary Oliveira Filho  1   2 , Leonardo Roever  3 , Alex Cleber Improta-Caria  1 , Roque Aras  1
Affiliations
Observational Study

Morbimortality and determinants of reperfusion in ischemic stroke

Adriana Ribeiro Oliveira et al. Rev Assoc Med Bras (1992). .

Abstract

Background: Cerebrovascular accident (or stroke) and ischemic heart disease are the the major causes of death in the world. It is estimated that about 85% of strokes are ischemic in origin. Reperfusion therapy in the acute phase of ischemic stroke with a recombinant human tissue plasminogen activator is effective, but some factors influence the success of this treatment.

Objective: The aim of this study was to evaluate clinical aspects and possible determinants for reperfusion after venous thrombolysis.

Methods: This is a retrospective, cross-sectional, observational study based on a review of hospital records of inpatients diagnosed with ischemic stroke treated with intravenous thrombolysis, the main outcome being reperfusion or not.

Results: Data from this study revealed a predominance of females in the group of reperfused patients and males in the non-reperfused group, both maintaining moderate severity on the National Institutes of Health Stroke Scale and admission without statistical significance (p>0.18). In addition, the mean admission severity score was 13.2 for the group of reperfused patients and 14.2 for those not reperfused, and the mean ejection fraction of both groups was within normal functionality, with a mean of 0.50 for reperfused patients and 0.62 for non-reperfused patients.

Conclusion: We found an association between successful venous chemical thrombolysis reperfusion and lower mortality in patients with acute stroke.

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Conflict of interest statement

Conflicts of interest: the authors declare there is no conflicts of interest.

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