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Editorial
. 2024 Jan 27;45(4):265-267.
doi: 10.1093/eurheartj/ehad826.

A conundrum of arterialized capillaries and vascular dilation in chronic limb-threatening ischaemia

Vijay C Ganta  1 , W Schuyler Jones  2 , Brian H Annex  1
Affiliations
Editorial

A conundrum of arterialized capillaries and vascular dilation in chronic limb-threatening ischaemia

Vijay C Ganta et al. Eur Heart J. .
No abstract available

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Figures

Graphical Abstract
Graphical Abstract
The contrast of the microvascular niche between healthy skeletal muscle (left) and muscle obtained from a patient is quite apparent. In muscle of a patient with chronic limb-threatening ischaemia (CLTI), muscle fibres are no longer normal; macrophages are proinflammatory (shown as cytotoxic), endothelial cells (ECs) have gone from all normal (left) to many that have undergone endothelial–mesenchymal transition (Endo-MT); smooth muscle cells (SMCs) have transitioned from normal to synthetic; proteins [small blue dots of vascular endothelial growth factor (VEGF) protein, for example] are less retained in the vasculature due to the increased permeability. ECs express VEGF receptor 2 (VEGFR2), but any action of VEGF should not be viewed as specific to ECs as other cell types with the microvascular niche express VEGFR1. What is not apparent is whether the process across all the cells is reversible, as shown by the broken arrow going from right to left
See this image and copyright information in PMC

Comment on

  • Critical limb-threatening ischaemia and microvascular transformation: clinical implications.
    Tarvainen S, Wirth G, Juusola G, Hautero O, Kalliokoski K, Sjöros T, Nikulainen V, Taavitsainen J, Hytönen J, Frimodig C, Happonen K, Selander T, Laitinen T, Hakovirta HH, Knuuti J, Laham-Karam N, Hartikainen J, Mäkinen K, Ylä-Herttuala S, Korpisalo P. Tarvainen S, et al. Eur Heart J. 2024 Jan 27;45(4):255-264. doi: 10.1093/eurheartj/ehad562. Eur Heart J. 2024. PMID: 37634134 Free PMC article.

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