Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul;47(7):1711-1717.
doi: 10.1007/s40618-023-02265-3. Epub 2023 Dec 21.

IgG4 serum levels in Graves' orbitopathy

S Comi #  1 , G Lanzolla #  1   2 , G Cosentino  1 , M N Maglionico  3 , C Posarelli  3 , F Menconi  1 , F Santini  1 , R Elisei  1 , M Marinò  4
Affiliations

IgG4 serum levels in Graves' orbitopathy

S Comi et al. J Endocrinol Invest. 2024 Jul.

Abstract

Objective: IgG4-related disease (IgG4-RD) can involve many organs, including thyroid and orbital tissues. A link between IgG4, Graves' disease (GD) and Graves' orbitopathy (GO) has been proposed, but results are conflicting. Here we investigated the possible association between IgG4 and GO.

Methods: Retrospective investigation in 297 patients with Graves' disease (GD), 152 with GO.

Primary outcome: prevalence of IgG4 ≥ 135 mg/dL (cut-off for IgG4-RD).

Secondary objectives: (1) serum IgG4 concentrations; (2) IgG4/IgG ratio; (3) prevalence of IgG4/IgG ratio ≥ 8.0%; (4) relationship between IgG4 and eye features; (5) relationship between IgG4 and anti-TSH receptor antibodies (TRAbs).

Results: Because GO patients had lower FT3 concentrations, we evaluated the main objectives in the second and third FT3 quartiles subpopulation, in which there were no relevant differences between patients with (n = 81) or without GO (n = 67) for baseline parameters. Within this population, the prevalence of IgG4 levels ≥ 135 mg/dL did not differ between patients without and with GO (17.9% vs 17.3%). No difference was observed concerning IgG4 concentrations, prevalence of IgG4/IgG ≥ 8.0%, and IgG4/IgG ratio. There was no relationship between IgG4 and eye features and no correlation between IgG4 levels and TRAb was found.

Conclusions: Our results suggest that, within GD, there is no relationship between serum IgG4 and GO.

Keywords: Graves’ disease; Graves’ orbitopathy; IgG4; Thyroid eye disease.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Stone JH, Zen Y, Deshpande V (2012) IgG4-related disease. N Engl J Med 366:539–551. https://doi.org/10.1056/NEJMra1104650 - DOI - PubMed
    1. Sato Y, Notohara K, Kojima M (2010) IgG4-related disease: historical overview and pathology of hematological disorders. Pathol Int 60(4):247–258. https://doi.org/10.1111/j.1440-1827.2010.02524.x - DOI - PubMed
    1. Kamisawa T, Funata N, Hayashi Y (2003) A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol 38(10):982–984. https://doi.org/10.1007/s00535-003-1175-y - DOI - PubMed
    1. Stone JH, Khosroshahi A, Hilgenberg A et al (2009) IgG4-related systemic disease and lymphoplasmacytic aortitis. Arthritis Rheum 60(10):3139–3145. https://doi.org/10.1002/art.24798 - DOI - PubMed
    1. Saeki T, Saito A, Hiura T et al (2006) Lymphoplasmacytic infiltration of multiple organs with immunoreactivity for IgG4: IgG4-related systemic disease. Intern Med 45(3):163–167. https://doi.org/10.2169/internalmedicine.45.1431 - DOI - PubMed

LinkOut - more resources