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Review
. 2024 Jun;29(5-6):570-585.
doi: 10.1007/s10495-023-01921-6. Epub 2023 Dec 21.

Exploring the role of ITGB6: fibrosis, cancer, and other diseases

Zhe Zhang #  1   2 , Zheng Wang #  3 , Tong Liu #  1   2 , Jiayou Tang  4 , Yanqing Liu  1   2 , Tiantian Gou  1   2 , Kangli Chen  1   2 , Li Wang  1   2 , Juan Zhang  1   2 , Yang Yang  5   6 , Huan Zhang  7   8
Affiliations
Review

Exploring the role of ITGB6: fibrosis, cancer, and other diseases

Zhe Zhang et al. Apoptosis. 2024 Jun.

Abstract

Integrin β6 (ITGB6), a member of the integrin family of proteins, is only present in epithelial tissues and frequently associates with integrin subunit αv to form transmembrane heterodimers named integrin αvβ6. Importantly, ITGB6 determines αvβ6 expression and availability. In addition to being engaged in organ fibrosis, ITGB6 is also directly linked to the emergence of cancer, periodontitis, and several potential genetic diseases. Therefore, it is of great significance to study the molecular-biological mechanism of ITGB6, which could provide novel insights for future clinical diagnosis and therapy. This review introduces the structure, distribution, and biological function of ITGB6. This review also expounds on ITGB6-related diseases, detailing the known biological effects of ITGB6.

Keywords: Cancer; Fibrosis; Heredopathia; ITGB6; Periodontitis.

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References

    1. Kechagia JZ, Ivaska J, Roca-Cusachs P (2019) Integrins as biomechanical sensors of the microenvironment. Nat Rev Mol Cell Biol 20:457–473. https://doi.org/10.1038/s41580-019-0134-2 - DOI - PubMed
    1. Moreno-Layseca P, Icha J, Hamidi H, Ivaska J (2019) Integrin trafficking in cells and tissues. Nat Cell Biol 21:122–132. https://doi.org/10.1038/s41556-018-0223-z - DOI - PubMed - PMC
    1. Humphries MJ (2000) Integrin structure. Biochem Soc Trans 28:311–339 - DOI - PubMed
    1. Takada Y, Ye X, Simon S (2007) The integrins. Genome Biol 8:215. https://doi.org/10.1186/gb-2007-8-5-215 - DOI - PubMed - PMC
    1. Chen W, Harbeck MC, Zhang W, Jacobson JR (2013) MicroRNA regulation of integrins. Translational Research: The Journal of Laboratory and Clinical Medicine 162:133–143. https://doi.org/10.1016/j.trsl.2013.06.008 - DOI - PubMed

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