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. 2023 Dec 22;382(6677):1363-1364.
doi: 10.1126/science.adm6771. Epub 2023 Dec 21.

An unexpected role for a glutamate receptor

Ian D Coombs  1 , Mark Farrant  1
Affiliations

An unexpected role for a glutamate receptor

Ian D Coombs et al. Science. .

Abstract

γ-Aminobutyric acid acts on a glutamate receptor, evoking synaptic plasticity.

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Figures

Figure 1
Figure 1. A new mediator of inhibitory plasticity.
GluD1 receptors form trans-synaptic complexes that include cerebellins (CBLN) and neurexin (NRXN). At an inhibitory hippocampal synapse, GluD1 can bind γ-aminobutyric acid (GABA), causing the potentiation of type A GABA (GABAA) receptor–mediated inhibitory postsynaptic currents (IPSCs). When GluD1 binds GABA (two of the four subunits are shown), it likely undergoes structural changes akin to those leading to gated and desensitized states in other ionotropic glutamate receptors, but the mechanism that leads to potentiated IPSCs is unknown.
See this image and copyright information in PMC

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