Metal-Organic Framework as a New Type of Magnetothermally-Triggered On-Demand Release Carrier

Xueying Ge^{1

2}, Jeotikanta Mohapatra³, Enya Silva⁴, Guihua He⁵, Lingshan Gong¹, Tengteng Lyu¹, Richa P Madhogaria⁴, Xin Zhao⁶, Yuchuan Cheng⁷, Abdullah M Al-Enizi⁸, Ayman Nafady⁸, Jian Tian⁵, J Ping Liu³, Manh-Huong Phan⁴, Francesca Taraballi⁹, Roderic I Pettigrew², Shengqian Ma¹

Affiliations

¹ Department of Chemistry, University of North Texas, Denton, Texas, 76201, USA.
² Engineering Medicine (EnMed), Texas A&M University and Houston Methodist Hospital, Houston, Texas, 77030, USA.
³ Department of Physics, The University of Texas at Arlington, Arlington, Texas, 76019, USA.
⁴ Department of Physics, University of South Florida, Tampa, Florida, 33620, USA.
⁵ Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, P. R. China.
⁶ J. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.
⁷ Zhejiang Key Laboratory of Additive Manufacturing Materials, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, P. R. China.
⁸ Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
⁹ Center for Musculoskeletal Regeneration, Orthopedics and Sports Medicine, Houston Methodist Hospital, Houston Methodist Academic Institute, Houston, Texas, 77030, USA.

PMID: 38127968
DOI: 10.1002/smll.202306940

Metal-Organic Framework as a New Type of Magnetothermally-Triggered On-Demand Release Carrier

Xueying Ge et al. Small. 2024 Mar.

. 2024 Mar;20(12):e2306940.

doi: 10.1002/smll.202306940. Epub 2023 Dec 21.

Authors

Affiliations

¹ Department of Chemistry, University of North Texas, Denton, Texas, 76201, USA.
² Engineering Medicine (EnMed), Texas A&M University and Houston Methodist Hospital, Houston, Texas, 77030, USA.
³ Department of Physics, The University of Texas at Arlington, Arlington, Texas, 76019, USA.
⁴ Department of Physics, University of South Florida, Tampa, Florida, 33620, USA.
⁵ Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, P. R. China.
⁶ J. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77843, USA.
⁷ Zhejiang Key Laboratory of Additive Manufacturing Materials, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, P. R. China.
⁸ Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
⁹ Center for Musculoskeletal Regeneration, Orthopedics and Sports Medicine, Houston Methodist Hospital, Houston Methodist Academic Institute, Houston, Texas, 77030, USA.

PMID: 38127968
DOI: 10.1002/smll.202306940

Abstract

The development of external stimuli-controlled payload systems has been sought after with increasing interest toward magnetothermally-triggered drug release (MTDR) carriers due to their non-invasive features. However, current MTDR carriers present several limitations, such as poor heating efficiency caused by the aggregation of iron oxide nanoparticles (IONPs) or the presence of antiferromagnetic phases which affect their efficiency. Herein, a novel MTDR carrier is developed using a controlled encapsulation method that fully fixes and confines IONPs of various sizes within the metal-organic frameworks (MOFs). This novel carrier preserves the MOF's morphology, porosity, and IONP segregation, while enhances heating efficiency through the oxidation of antiferromagnetic phases in IONPs during encapsulation. It also features a magnetothermally-responsive nanobrush that is stimulated by an alternating magnetic field to enable on-demand drug release. The novel carrier shows improved heating, which has potential applications as contrast agents and for combined chemo and magnetic hyperthermia therapy. It holds a great promise for magneto-thermally modulated drug dosing at tumor sites, making it an exciting avenue for cancer treatment.

Keywords: hyperthermia treatment; iron oxide nanoparticles; magnetothermal; metal–organic frameworks; on‐demand drug release.

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References

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Metal-Organic Framework as a New Type of Magnetothermally-Triggered On-Demand Release Carrier

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Metal-Organic Framework as a New Type of Magnetothermally-Triggered On-Demand Release Carrier

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