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Comment
. 2023 Dec 20;14(12):1021-1023.
doi: 10.1016/j.cels.2023.11.002.

Modeling elucidates context dependence in adipose regulation

Cameron D Vasquez  1 , John G Albeck  2
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Comment

Modeling elucidates context dependence in adipose regulation

Cameron D Vasquez et al. Cell Syst. .
Free article

Abstract

Single-cell data and computational simulations reveal the dynamics of the transcription factors HIF1α and PPARγ during adipocyte differentiation and maturation. Modeling feedback within this network predicts a HIF1α-mediated choice between lipid accumulation and incomplete differentiation. In vitro experiments support this model, with implications for adipose dynamics in metabolic disorders involving hypoxia.

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Conflict of interest statement

Declaration of interests John Albeck is a member of the Cell Systems Advisory Board.

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