Gastro-oesophageal reflux and idiopathic pulmonary fibrosis: sorting the chicken and the egg by genetic link
- PMID: 38128953
- PMCID: PMC10990001
- DOI: 10.1183/13993003.01878-2023
Gastro-oesophageal reflux and idiopathic pulmonary fibrosis: sorting the chicken and the egg by genetic link
Conflict of interest statement
Conflict of interest: G. Raghu reports grants from NHLBI/NIH, consulting fees from BMS, United Therapeutics, Fibrogen and Veracyte, advisory board participation with Avalyn, leadership roles with ATS (IPF guideline chair) and the Pulmonary Fibrosis Foundation (scientific advisory board), and other interests with Bellerophan, Gilead, Nitto, Novartis and Roche-Hoffman-Genentech (as unpaid consultant for IPF studies) and BI (as scientific reviewer for investigator initiated grant proposals), outside the submitted work. C.A. Newton reports support for the present work from NIH NHLBI (grant number K23HL148498); outside the submitted work, C.A. Newton reports consulting fees from Boehringer Ingelheim. I. Noth reports support for the present manuscript from NIH (grant number UG3HL145266); outside the submitted work, I. Noth reports grants from Veracyte, and consulting fees from Boehringer Ingelheim and Sanofi.
Comment on
-
Mediators of the association between gastro-oesophageal reflux disease and idiopathic pulmonary fibrosis.Eur Respir J. 2023 Dec 21;62(6):2300323. doi: 10.1183/13993003.00323-2023. Print 2023 Dec. Eur Respir J. 2023. PMID: 37857422 No abstract available.
References
-
- Chen B, You WJ, Liu XQ, et al. Chronic microaspiration of bile acids induces lung fibrosis through multiple mechanisms in rats. Clin Sci (Lond) 2017; 131: 951–963. - PubMed
-
- Downing TE, Sporn TA, Bollinger RR, et al. Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity. Exp Biol Med (Maywood) 2008; 233: 1202–1212. - PubMed
-
- Chen B, Cai HR, Xue S, et al. Bile acids induce activation of alveolar epithelial cells and lung fibroblasts through farnesoid X receptor-dependent and independent pathways. Respirology 2016; 21: 1075–1080. - PubMed
-
- Tobin R, Pope C, Pelligrini C, et al. Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1998; 158: 1804–1808. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical