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. 2024 Mar 7;73(4):568-572.
doi: 10.1136/gutjnl-2023-331335.

ForePass endoscopic bypass device for obesity and insulin resistance-metabolic treatment in a swine model

Giulia Angelini  1 , Manoel Galvao Neto  2 , Ivo Boskoski  3 , Maria Emiliana Caristo  4 , Sara Russo  5 , Luca Proto  6 , Elena Previti  5 , Lisa Olsson  7 , Hobby Aggarwal  8 , Samantha Pezzica  9 , Elisa Ferrari  9 , Vincenzo Bove  3 , Alfredo Genco  10 , Stefan Bornstein  11 , Valentina Tremaroli  12 , Amalia Gastaldelli  9 , Geltrude Mingrone  5   6   13
Affiliations

ForePass endoscopic bypass device for obesity and insulin resistance-metabolic treatment in a swine model

Giulia Angelini et al. Gut. .
No abstract available

Keywords: ENDOSCOPIC PROCEDURES; OBESITY SURGERY.

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Conflict of interest statement

Competing interests: GA reports consulting fees from Metadeq and GHP Scientific. IB reports consulting fees from Apollo, Endosurgery, AndoTools, Nitinotes, Erbe Elektromedizin, Boston Scientific, Cook Medical and Pentax Medical. MGN reports consulting fees from Apollo EndoSurgery, USGI and Keyron. He is also a Scientific Advisor of Keyron and Morphic Medical. VB reports consulting fees from Apollo EndoSurgery. GM reports consulting fees from Novo Nordisk, Fractyl, Recor. She is also Scientific Advisor of Keyron, Metadeq, GHP Scientific, and Jemyll. All other authors declare no competing interests.

Figures

Figure 1
Figure 1
Characteristics of the Forepass device. (A) The overall structure of the ForePass device, which is composed of a silicone gastric balloon and an expanded polytetrafluoroethylene (EPTFE) intestinal sleeve. A nitinol stent-like funnel, which traverses the balloon, connects to the sleeve. The transplyloric stent, coated by EPTFE, helps to improve device stability. (B) An endoscopic image of the proximal end of the ForePass device, including the inflated gastric balloon. The balloon’s colour is due to methylene blue added to the saline solution used to inflate the device. (C) An X-ray fluoroscopy image of the ForePass device positioned in the stomach and proximal gut. The balloon component of the device is placed in the stomach, while the transpyloric stent and intestinal sleeve are located further down, past the pylorus.
Figure 2
Figure 2
Metabolic shifts after ForePass. (A–C) Time courses and areas under the curve (AUCs) of blood glucose (A), plasma insulin (B), and plasma C-peptide (C) during an intragastric glucose administration (75g) using a combination of ingested and infused stable isotopically labelled glucose tracers in both ForePassTM and sham-operated pigs (Sham-Op). (D–F) Time courses and AUCs of the rate of appearance of exogenous glucose (Ra) (D), glucose rate of disappearance (Rd) (E), and endogenous glucose production. (G) Principal component analysis explains 85.8% of the variance of metabolites that significantly differ between ForePass and Sham-operation. (H) Heat map of polar metabolites 4 weeks after the interventions. Data are presented as mean values±SEM (n=4 pigs per group). Statistical significance values were calculated by Mann-Whitney U test and repeated measure analysis of variance were appropriate.
See this image and copyright information in PMC

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