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. 2023 Dec 22;28(1):12.
doi: 10.1007/s00784-023-05412-5.

Females with painful temporomandibular disorders present higher intracortical facilitation relative to pain-free controls

Alberto Herrero Babiloni  1   2 , Marianne Jodoin  3   4 , Catherine Provost  3 , Camille Charlebois-Plante  3   4 , Beatrice P De Koninck  3   4 , Amelie Apinis-Deshaies  3 , Gilles J Lavigne  5   3   6 , Louis De Beaumont  3   4
Affiliations

Females with painful temporomandibular disorders present higher intracortical facilitation relative to pain-free controls

Alberto Herrero Babiloni et al. Clin Oral Investig. .

Abstract

Objectives: This study aimed to investigate cortical excitability differences in the primary motor cortex (M1) hand representation between individuals with temporomandibular disorders (TMD) and healthy controls. We assessed resting motor thresholds, motor-evoked potentials (MEPs), intracortical inhibition, and intracortical facilitation and explored potential associations with clinical and psychosocial characteristics in the TMD group.

Materials and methods: We recruited 36 female participants with TMD and 17 pain-free controls. Transcranial magnetic stimulation (TMS) was used to assess M1 cortical excitability. Correlations between clinical and psychosocial factors and cortical excitability measures were also evaluated.

Results: Patients with TMD showed significantly higher intracortical facilitation at 12 ms (z = 1.98, p = 0.048) and 15 ms (z = 2.65, p = 0.008) when compared to controls. Correlations revealed associations between intracortical facilitation and pain interference, sleep quality, depressive symptoms, and pain catastrophizing in the TMD group.

Conclusions: Females with TMD exhibit heightened motor cortex intracortical facilitation in the hand representation, potentially indicating altered cortical excitability beyond the motor face area. This suggests a role for cortical excitability in TMD pathophysiology, influenced by psychosocial factors.

Clinical relevance: Understanding cortical excitability in TMD may inform targeted interventions. Psychosocial variables may play a role in cortical excitability, emphasizing the multidimensional nature of TMD-related pain. Further research is needed to confirm and expand upon these findings, with potential implications for the management of TMD and related pain conditions.

Keywords: Cortical excitability; Orofacial pain; Temporomandibular joint disorders; Transcranial magnetic stimulation.

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