Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec 21;23(1):2552.
doi: 10.1186/s12889-023-17440-7.

Significantly reduced incidence and improved survival from prostate cancer over 25 years

Bernat Carles Serdà-Ferrer  1 , Arantza Sanvisens  2 , Rafael Fuentes-Raspall  3 , Montse Puigdemont  2 , Xavier Farré  4 , Anna Vidal-Vila  2 , Martí Rispau-Pagès  5 , Alicia Baltasar-Bagué  6 , Rafael Marcos-Gragera  6   2
Affiliations

Significantly reduced incidence and improved survival from prostate cancer over 25 years

Bernat Carles Serdà-Ferrer et al. BMC Public Health. .

Abstract

Background: Prostate cancer (PCa) was the second most frequent cancer and the fifth leading cause of cancer death among men in 2020. The aim of this study was to analyze trends in the incidence, mortality and survival of PCa in Girona, Spain, over 25 years.

Methods: Population-based study of PCa collected in the Girona Cancer Registry, 1994-2018. Age-adjusted incidence and mortality rates were calculated per 100,000 men-year. Joinpoint regression models were used for trends, calculating the annual percentage changes (APC). Observed and net survival were analyzed using Kaplan-Meier and Pohar-Perme estimations, respectively.

Results: A total of 9,846 cases of PCa were registered between 1994-2018. The age-adjusted incidence and mortality rates were 154.7 (95%CI: 151.7 157.8) and 38.9 (95%CI: 37.3 -40.6), respectively. An increased incidence of 6.2% was observed from 1994 to 2003 (95%CI: 4.4 -8.1), and a decrease of -2.7% (95%CI: -3.5 -;-1.9) between 2003 and 2018. Mortality APC was -2.6% (95%CI: -3.3 --2.0). Five-year observed and net survival were 72.8% (95%CI: 71.8 - 73.7) and 87.2% (95%CI: 85.9 - 88.4), respectively. Five-year net survival increased over time from 72.9% (1994-1998) to 91.3% (2014-2018).

Conclusions: The analyses show a clear reduction in PCa incidence rates from 2003 on, along with an increase in overall survival when comparing the earlier period with more recent years.

Keywords: Epidemiology; Incidence; Mortality; Prostate cancer; Survival; Temporal trends.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Trends in mean age of diagnosis, incidence and mortality rates of PCa in Girona, 1994–2018
Fig. 2
Fig. 2
Overall and age-specific 5- and 10-year net survival of PCa in Girona by period of diagnosis
See this image and copyright information in PMC

References

    1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. Gandaglia G, Leni R, Bray F, Fleshner N, Freedland SJ, Kibel A, et al. Epidemiology and prevention of prostate cancer. European Urol Oncol. 2021;4:877–892. doi: 10.1016/j.euo.2021.09.006. - DOI - PubMed
    1. National Cancer Institute. Prostate Cancer Prevention (PDQ(R)): Health Professional Version. CancerGov. 2002:1–24. https://www.cancer.gov/types/prostate/hp/prostate-prevention-pdq. Accessed 9 Aug 2022
    1. Ubago-Guisado E, Rodríguez-Barranco M, Ching-López A, Petrova D, Molina-Montes E, Amiano P, et al. Evidence update on the relationship between diet and the most common cancers from the european prospective investigation into cancer and nutrition (Epic) study: A systematic review. Nutrients. 2021;13:3582. doi: 10.3390/nu13103582. - DOI - PMC - PubMed
    1. Silva JFS, Mattos IE, Luz LL, Carmo CN, Aydos RD. Exposure to pesticides and prostate cancer: Systematic review of the literature. Rev Environ Health. 2016;31:311–327. doi: 10.1515/reveh-2016-0001. - DOI - PubMed