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Editorial
. 2023 Nov 30;12(11):2984-2988.
doi: 10.21037/tcr-23-1570. Epub 2023 Oct 27.

Interplay of homologous-recombination genes and Helicobacter pylori in gastric cancer susceptibility

Fabian Fellipe Bueno Lemos  1 , Fabrício Freire de Melo  1
Affiliations
Editorial

Interplay of homologous-recombination genes and Helicobacter pylori in gastric cancer susceptibility

Fabian Fellipe Bueno Lemos et al. Transl Cancer Res. .
No abstract available

Keywords: CagA; Gastric cancer (GC); Helicobacter pylori (H. pylori); homologous-recombination genes (HR genes); virulence factors.

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Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-23-1570/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Basic illustration: how homologous recombination genes and H. pylori interact in gastric cancer susceptibility. Phosphorylation-triggered translocation of CagA to the inner lipid layer of the plasma membrane is depicted. Functioning as a versatile scaffold or hub protein, CagA simultaneously disrupts multiple host signaling pathways. These pathways play a pivotal role in regulating various cellular processes including proliferation, differentiation, and apoptosis. The resultant incongruent interaction between CagA and host proteins leads to oncogenic alterations in cells. The potential link between the alignment of pro-oncogenic insults and variations in cancer-predisposing host genes is proposed to be connected with the progression to gastric cancer. H. pylori, Helicobacter pylori.
See this image and copyright information in PMC

Comment on

  • Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer.
    Usui Y, Taniyama Y, Endo M, Koyanagi YN, Kasugai Y, Oze I, Ito H, Imoto I, Tanaka T, Tajika M, Niwa Y, Iwasaki Y, Aoi T, Hakozaki N, Takata S, Suzuki K, Terao C, Hatakeyama M, Hirata M, Sugano K, Yoshida T, Kamatani Y, Nakagawa H, Matsuda K, Murakami Y, Spurdle AB, Matsuo K, Momozawa Y. Usui Y, et al. N Engl J Med. 2023 Mar 30;388(13):1181-1190. doi: 10.1056/NEJMoa2211807. N Engl J Med. 2023. PMID: 36988593

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