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Case Reports
. 2023 Dec 7:10:1227799.
doi: 10.3389/fvets.2023.1227799. eCollection 2023.

Case report: A case of oviductal and uterine leiomyosarcoma in an 11-year-old dog

Jillian Kazmierczak  1 , Nicole J Sugai  2 , Katie E Withowski  3 , Abe Jonatan  2 , Tanya LeRoith  4 , Julie T Cecere  2
Affiliations
Case Reports

Case report: A case of oviductal and uterine leiomyosarcoma in an 11-year-old dog

Jillian Kazmierczak et al. Front Vet Sci. .

Abstract

An 11-year-old, intact female Pomeranian dog was presented for evaluation due to an 18-h history of anorexia and lethargy. Abdominal ultrasound revealed a 3×3 cm mass of mixed echogenicity at the level of the left ovary. At laparotomy, a 5 mm mass was identified at the cranial region of the right uterine horn and a 3 cm round mass was visualized near the cranial aspect of the left uterine horn. Ovariohysterectomy was performed. A diagnosis of grade 1 oviductal and uterine leiomyosarcoma was made via histopathology for both masses. Oviductal leiomyosarcomas are rare and generally locally invasive similar to other soft tissue sarcomas but do not often metastasize. Uterine leiomyosarcomas are also uncommon but are one of the more common tumors affecting the female reproductive tract. This is the only known case report of oviductal leiomyosarcoma in the dog and the only report of uterine leiomyosarcoma in addition to oviductal leiomyosarcoma as well. This case illustrates the oviduct as an additional site that can be affected by leiomyosarcoma and demonstrates surgery as a treatment option for patients diagnosed with this condition.

Keywords: dog; neoplasia; oviduct; oviductal leiomyosarcoma; oviductal mass; uterine leiomyosarcoma; uterine mass; uterus.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Excised uterus and ovaries from the patient. The left and right ovaries appeared grossly normal and are identified by the black arrows. The 3 cm left oviductal mass is identified by the black star. The 5 mm mass in the right uterine horn is identified by the black triangle. The uterine body and cervix appeared grossly normal and are identified by the black circle.
Figure 2
Figure 2
Histopathological results of excisional biopsy highlighting grade 1 uterine and oviductal leiomyosarcoma. Photomicrographs of hematoxylin and eosin-stained preserved tissue samples. (A) Spindle-shaped cells with indistinct cellular borders, eosinophilic cytoplasm, and eosinophilic cellular matrix. (B–E) Abnormal spindle-shaped cells are organized in sheets and bundles. (F) Abnormal spindle cell population infiltrating the oviductal and uterine smooth muscle tissue.
Figure 3
Figure 3
Histopathologic results of excisional biopsy highlighting tissue distinction. 200x, Masson’s Trichrome. The smooth muscle sarcoplasm is red, perivascular and stromal mesenchymal cells are blue.
See this image and copyright information in PMC

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