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. 2023 Dec 21:4:24.
doi: 10.17879/freeneuropathology-2023-5227. eCollection 2023 Jan.

Adrenomyeloneuropathy (AMN): myelinopathy or axonopathy?: Comment on: Considering the myelin-centric hypothesis: insights from Budka's historical adrenomyeloneuropathy case report by E. Salsano and C. Benzoni

Herbert Budka  1
Affiliations

Adrenomyeloneuropathy (AMN): myelinopathy or axonopathy?: Comment on: Considering the myelin-centric hypothesis: insights from Budka's historical adrenomyeloneuropathy case report by E. Salsano and C. Benzoni

Herbert Budka. Free Neuropathol. .
No abstract available

Keywords: Adrenomyeloneuropathy (AMN); Axonopathy; Demyelination; Myelinopathy.

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Figures

Figure 1
Figure 1
Moderate diffuse loss of axonal profiles. IHC with anti-pNFPs (SMI31) x 40.
Figure 2
Figure 2
Disseminated axonal swellings. IHC with anti-pNFPs (SMI31) x 200.
Figure 3
Figure 3
In center, a large axonal swelling surrounded by normally appearing myelin sheath. LFB and nuclear fast red x 500.
Figure 4
Figure 4
Axonal swellings contain p62. IHC with anti-p62 (clone 3/p62 lck ligand, BD Transduction Laboratories, Franklin Lakes, NJ, USA) x 100.
Figure 5
Figure 5
Axonal swellings contain ubiquitin. IHC with anti-ubiquitin (clone Ubi-1, aka 042691GS, Millipore, Burlington, MA, USA) x 100.
Figure 6
Figure 6
A tegmental neuron with pNFPs in its cell body in the upper right corner; other neurons are negative. IHC with anti-pNFPs (SMI31) x 200.
See this image and copyright information in PMC

References

    1. Salsano E, Benzoni C: Considering the myelin-centric hypothesis: insights from Budka's historical adrenomyeloneuropathy case report. Free Neuropathol. 4: 23 (2023). 10.17879/freeneuropathology-2023-5218 - DOI - PMC - PubMed
    1. Budka H, Sluga E, Heiss WD: Spastic paraplegia associated with Addison’s disease: adult variant of adreno-leukodystrophy. J Neurol. 213: 237–250 (1976). 10.1007/BF00312873 - DOI - PubMed
    1. Budka H: A historical look using virtual microscopy: the first case report of adrenomyeloneuropathy (AMN). Free Neuropathol. 4: 18 (2023). 10.17879/freeneuropathology-2023-5115 - DOI - PMC - PubMed
    1. Moore GRW, Stadelmann-Nessler C: Demyelinating Diseases. In: Love S, Budka, H, Ironside JW, Perry A (eds.) Greenfield’s Neuropathology, 9th ed., vol. 2, pp. 1297-1412. CRC Press, Boca Raton FL 2015.
    1. Faust PL, Powers JM: Peroxisomal disorders. In: Love S, Budka, H, Ironside JW, Perry A (eds.) Greenfield’s Neuropathology, 9th ed., vol. 1, pp. 562-588. CRC Press, Boca Raton FL 2015.

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