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Review
. 2023 Dec 6;11(34):8111-8125.
doi: 10.12998/wjcc.v11.i34.8111.

Research progress on the relationship between Paneth cells-susceptibility genes, intestinal microecology and inflammatory bowel disease

Qi-Ming Zhou  1 , Lie Zheng  2
Affiliations
Review

Research progress on the relationship between Paneth cells-susceptibility genes, intestinal microecology and inflammatory bowel disease

Qi-Ming Zhou et al. World J Clin Cases. .

Abstract

Inflammatory bowel disease (IBD) is a disorder of the immune system and intestinal microecosystem caused by environmental factors in genetically susceptible people. Paneth cells (PCs) play a central role in IBD pathogenesis, especially in Crohn's disease development, and their morphology, number and function are regulated by susceptibility genes. In the intestine, PCs participate in the formation of the stem cell microenvironment by secreting antibacterial particles and play a role in helping maintain the intestinal microecology and intestinal mucosal homeostasis. Moreover, PC proliferation and maturation depend on symbiotic flora in the intestine. This paper describes the interactions among susceptibility genes, PCs and intestinal microecology and their effects on IBD occurrence and development.

Keywords: Inflammatory bowel disease; Intestinal microecology; Paneth cells; Susceptibility gene.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Physiological function of Paneth cells.
Figure 2
Figure 2
Paneth cells and intestinal inflammation. TNF: Tumor necrosis factor.
See this image and copyright information in PMC

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