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Review
. 2024 Feb;16(4):249-257.
doi: 10.2217/epi-2023-0297. Epub 2023 Dec 22.

SET protein as an epigenetics target

Gabriel da Silva  1 , Thaís Moré Milan  1 , Pablo Shimaoka Chagas  1 , Glauce Lunardelli Trevisan  1 , Camila Lopes Ferraz  1 , Andréia Machado Leopoldino  1
Affiliations
Review

SET protein as an epigenetics target

Gabriel da Silva et al. Epigenomics. 2024 Feb.

Abstract

The SET gene has four transcripts reported in NCBI, coding two isoforms of SET proteins. The most known function of SET protein is inhibiting protein phosphatase 2A, a tumor suppressor, which has been associated with different biological processes. In this review, our focus was on exploring the other SET functions related to epigenetic mechanisms, which impact cellular migration, cell cycle and apoptosis.

Keywords: Alzheimer's; I2PP2A; SET protein; cancer; epigenetics.

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