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. 2024 Feb;44(2):286-292.
doi: 10.1111/liv.15821. Epub 2023 Dec 22.

Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital

Anna Pocurull  1   2 , Maria José Moreta  1 , David Heitman  1 , Ignasi Olivas  1   2 , Cristina Collazos  1 , Elia Canga  1 , Joaquin Sáez-Peñataro  3 , Raul J Andrade  2   4 , M Isabel Lucena  2   4 , Zoe Mariño  1   2 , Alba Díaz  2   5 , Sabela Lens  1   2 , María Carlota Londoño  1   2 , Xavier Forns  1   2
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Anticancer drugs are the first cause of drug-induced liver injury in a reference hospital

Anna Pocurull et al. Liver Int. 2024 Feb.

Abstract

Drug-induced liver injury (DILI) is a challenging liver disorder for hepatologists. We aimed to assess the pattern and causes of DILI in a tertiary hospital. We registered prospectively all patients referred with suspicion of DILI from 2018 to 2023. A total of 106 patients fulfilled the diagnostic criteria (30 caused by paracetamol were excluded; total number 76). The pattern of liver injury was hepatocellular in 55 (72%). Drugs causing DILI were antineoplastic (26%), antibiotics (24%), analgesics (12%), and recreational drugs (9%). Regarding clinical outcomes, 39 (51%) required hospitalization and 7 (9%) underwent a liver transplantation or died from acute liver injury. We identified 126 additional patients with DILI due to immune check-point inhibitors who were not referred to a liver disease specialist. Antineoplastic drugs have become the first cause of DILI in hospitals. A multidisciplinary approach and specific educational tools to increase DILI awareness are needed among different specialists.

Keywords: antineoplastic drugs; diagnosis; oncologists.

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References

REFERENCES

    1. Fontana RJ, Bjornsson ES, Reddy R, Andrade RJ. The evolving profile of idiosyndratic drug-induced liver injury. Clin Gastroenterol Hepatol. 2023;21:2088-2099.
    1. Björnsson ES. Epidemiology, predisposing factors, and outcomes of drug-induced liver injury. Clin Liver Dis. 2020;24:1-10.
    1. Fontana RJ, Hayashi PH, Gu J, et al. Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onset. Gastroenterology. 2014;147:96-108.
    1. Andrade RJ, Lucena MI, Fernández MC, et al. Drug-induced liver injury: an análisis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology. 2005;129:512-521.
    1. EASL Clinical Practice Guidelines. Drug-induced liver injury. J Hepatol. 2019;70:1222-1261.

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