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Review
. 2023 Dec 13;10(12):495.
doi: 10.3390/jcdd10120495.

Genetics in Ischemic Stroke: Current Perspectives and Future Directions

Ka Zhang  1 , Shaun S E Loong  2   3 , Linus Z H Yuen  3 , Narayanaswamy Venketasubramanian  4 , Hui-Lin Chin  5 , Poh San Lai  6 , Benjamin Y Q Tan  1   3
Affiliations
Review

Genetics in Ischemic Stroke: Current Perspectives and Future Directions

Ka Zhang et al. J Cardiovasc Dev Dis. .

Abstract

Ischemic stroke is a heterogeneous condition influenced by a combination of genetic and environmental factors. Recent advancements have explored genetics in relation to various aspects of ischemic stroke, including the alteration of individual stroke occurrence risk, modulation of treatment response, and effectiveness of post-stroke functional recovery. This article aims to review the recent findings from genetic studies related to various clinical and molecular aspects of ischemic stroke. The potential clinical applications of these genetic insights in stratifying stroke risk, guiding personalized therapy, and identifying new therapeutic targets are discussed herein.

Keywords: genetics; genome-wide association studies (GWASs); ischemic stroke; pharmacogenetics; pharmacogenomics; stroke recovery.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Breakdown of the pathophysiological mechanisms of ischemic stroke. Potential genetic factors based on underlying stroke mechanism are highlighted, including various subtype-based molecular pathways that contributes to neuronal death. The double-helix sign highlights mechanisms which have been identified to have genetic underpinnings. AF: atrial fibrillation; PRV: polycythemia rubra vera; ET: essential thrombocythemia.
Figure 2
Figure 2
Broad overview of the various approaches used for the elucidation of the molecular underpinnings of ischemic stroke, focusing on current and future directions of genetics approaches.
See this image and copyright information in PMC

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