Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Nov 21;11(12):947.
doi: 10.3390/toxics11120947.

Aerosol Emissions from Heated Tobacco Products: A Review Focusing on Carbonyls, Analytical Methods, and Experimental Quality

Roberto A Sussman  1 , Federica Sipala  2   3 , Rosalia Emma  3   4 , Simone Ronsisvalle  2   3
Affiliations
Review

Aerosol Emissions from Heated Tobacco Products: A Review Focusing on Carbonyls, Analytical Methods, and Experimental Quality

Roberto A Sussman et al. Toxics. .

Abstract

We provide an extensive review of 17 independent and industry-funded studies targeting carbonyls in aerosol emissions of Heated Tobacco Products (HTPs), focusing on quality criteria based on the reproducibility of experiments, appropriate analytic methods, and puffing regimes. Most revised studies complied with these requirements, but some were unreproducible, while others failed to consider analytical variables that may have affected the results and/or produced unrealistic comparisons. We also provide a review of the literature on the physicochemical properties of heated tobacco and HTP aerosols, as well as the evaluation of HTPs by regulatory agencies, addressing various critiques of their relative safety profile. The outcomes from the revised studies and regulatory evaluations tend to agree with and converge to a general consensus that HTP aerosols expose users to significantly lower levels of toxicity than tobacco smoke.

Keywords: aerosols; analytical methods; carbonyls; heated tobacco products.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA-recommended workflow.
Figure 2
Figure 2
Methodological flow diagram.
See this image and copyright information in PMC

References

    1. Centers for Disease Control and Prevention (US) National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health (US) How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General. Centers for Disease Control and Prevention (US); Atlanta GA, USA: 2010. - PubMed
    1. World Health Organization . WHO Report on The Global Tobacco Epidemic, 2017. Monitoring Tobacco Use and Prevention Policies. World Health Organization; Geneva, Switzerland: 2017.
    1. Caponnetto P., Keller E., Bruno C.M., Polosa R. Handling relapse in smoking cessation: Strategies and recommendations. Intern. Emerg. Med. 2013;8:7–12. doi: 10.1007/s11739-012-0864-z. - DOI - PubMed
    1. Kotz D., Batra A., Kastaun S. Smoking Cessation Attempts and Common Strategies Employed. Dtsch. Arztebl. Int. 2020;117:7–13. doi: 10.3238/arztebl.2020.0007. - DOI - PMC - PubMed
    1. Shapiro H. Burning Issues: Global State of Tobacco Harm Reduction 2020. Knowledge-Action-Change; London, UK: 2020.

LinkOut - more resources