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. 2023 Dec 14;8(12):520.
doi: 10.3390/tropicalmed8120520.

High Tuberculosis Preventive Treatment Uptake and Completion Rates Using a Person-Centered Approach among Tuberculosis Household Contact in Yogyakarta

Felisia Felisia  1 , Rina Triasih  1   2 , Betty Weri Yolanda Nababan  1 , Guardian Yoki Sanjaya  3 , Setyogati Candra Dewi  4 , Endang Sri Rahayu  4 , Lana Unwanah  4 , Philipp du Cros  5 , Geoffrey Chan  5
Affiliations

High Tuberculosis Preventive Treatment Uptake and Completion Rates Using a Person-Centered Approach among Tuberculosis Household Contact in Yogyakarta

Felisia Felisia et al. Trop Med Infect Dis. .

Abstract

Coverage of tuberculosis preventive treatment (TPT) in Indonesia is inadequate, and persons who start TPT often do not complete treatment. In 2020, Zero TB Yogyakarta implemented person-centered contact investigation and shorter TPT regimen provision in collaboration with primary health care centers. Between 1 January 2020 and 31 August 2022, we assessed eligibility for TPT among household contacts of persons with bacteriologically confirmed TB (index cases) and offered them a 3-month TPT regimen (3RH or 3HP). A dedicated nurse monitored contacts on TPT for treatment adherence and side effects every week in the first month and every two weeks in the next months. Contacts were also able to contact a nurse by phone or ask for home visits at any point if they had any concerns. A total of 1016 contacts were eligible for TPT: 772 (78.8%) started short regimen TPT with 706 (91.5%) completing their TPT. Side effects were reported in 26 (39%) of the non-completion group. We conclude that high rates of TPT uptake and completion among contacts assessed as eligible for TPT can be achieved through person-centered care and the use of shorter regimens. Side-effect monitoring and management while on TPT is vital for improving TPT completion.

Keywords: person-centered care; short regimen; tuberculosis preventive treatment (TPT).

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Map of Yogyakarta Province.
Figure 2
Figure 2
The cascade of care for TPT in YY and KP from January 2020 to August 2022.
Figure 3
Figure 3
Proportion of contacts on short TPT regimens who reported side effects by month of first report of side effect.
See this image and copyright information in PMC

References

    1. World Bank Group The World Bank. [(accessed on 5 August 2022)]. Available online: https://data.worldbank.org/indicator/SH.TBS.INCD?locations=ID.
    1. Auld S.C., Shah N.S., Cohen T., Martinson N.A., Gandhi N.R. Where Is Tuberculosis Transmission Happening? Insights from the Literature, New Tools to Study Transmission and Implications for the Elimination of Tuberculosis. Respirology. 2018;23:807–817. doi: 10.1111/resp.13333. - DOI - PMC - PubMed
    1. Fox G.J., Barry S.E., Britton W.J., Marks G.B. Contact Investigation for Tuberculosis: A Systematic Review and Meta-Analysis. Eur. Respir. J. 2013;41:140–156. doi: 10.1183/09031936.00070812. - DOI - PMC - PubMed
    1. Morrison J., Pai M., Hopewell P.C. Tuberculosis and Latent Tuberculosis Infection in Close Contacts of People with Pulmonary Tuberculosis in Low-Income and Middle-Income Countries: A Systematic Review and Meta-Analysis. Lancet Infect. Dis. 2008;8:359–368. doi: 10.1016/S1473-3099(08)70071-9. - DOI - PubMed
    1. Verver S., Warren R.M., Munch Z., Richardson M., van der Spuy G.D., Borgdorff M.W., Behr M.A., Beyers N., Helden P.D. van Proportion of Tuberculosis Transmission That Takes Place in Households in a High-Incidence Area. Lancet. 2004;363:212–214. doi: 10.1016/S0140-6736(03)15332-9. - DOI - PubMed

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