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Comment
. 2023 Dec 21;30(12):1505-1507.
doi: 10.1016/j.chembiol.2023.11.014.

Knocking off cancer's HAT: CSS1477 disrupts oncogenic programs

Luyao Kevin Xu  1 , Panagiotis Ntziachristos  2
Affiliations
Free article
Comment

Knocking off cancer's HAT: CSS1477 disrupts oncogenic programs

Luyao Kevin Xu et al. Cell Chem Biol. .
Free article

Abstract

EP300/CBP are histone acetyltransferases recruited onto chromatin by oncogenic transcription factors and control the transcriptional program via their activity in enhancer areas. In the December issue of Cancer Cell, Nicosia et al.1 offer new promise in targeting EP300/CBP using the small-molecule inhibitor CSS1477 in patients with blood tumors and no other therapeutic options.

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Conflict of interest statement

Declaration of interests L.K.X. is an employee of AstraZeneca.

Comment on

  • Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies.
    Nicosia L, Spencer GJ, Brooks N, Amaral FMR, Basma NJ, Chadwick JA, Revell B, Wingelhofer B, Maiques-Diaz A, Sinclair O, Camera F, Ciceri F, Wiseman DH, Pegg N, West W, Knurowski T, Frese K, Clegg K, Campbell VL, Cavet J, Copland M, Searle E, Somervaille TCP. Nicosia L, et al. Cancer Cell. 2023 Dec 11;41(12):2136-2153.e13. doi: 10.1016/j.ccell.2023.11.001. Epub 2023 Nov 22. Cancer Cell. 2023. PMID: 37995682

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