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Review
. 2023 Dec 7;10(12):1896.
doi: 10.3390/children10121896.

Worldwide Variations in Fluoride Content in Beverages for Infants

Eleonor Velez-León  1   2   3 , Edisson-Mauricio Pacheco-Quito  1   2   3 , Mario Díaz-Dosque  3   4 , Daniela Tobar-Almache  3   4
Affiliations
Review

Worldwide Variations in Fluoride Content in Beverages for Infants

Eleonor Velez-León et al. Children (Basel). .

Abstract

In situations where breastfeeding is impractical, milk formulas have emerged as the primary choice for infant nutrition. Numerous global studies have scrutinized the fluoride content in these formulas, uncovering fluctuations in fluoride levels directly associated with the method of preparation. This variability poses a potential risk of elevated fluoride concentrations and, consequently, an increased susceptibility to dental fluorosis in infants. The primary objective of this review is to intricately delineate the fluoride content in dairy formulas and emphasize the variability of these values concerning their reconstitution process. The review's findings reveal that, among the 17 studies assessing fluoride levels in infant formula, milk-based formulas exhibit a range of 0.01-0.92 ppm, with only two studies exceeding 1.30 ppm. Conversely, soy-based formulas demonstrate values ranging from 0.13-1.11 ppm. In conclusion, the observed variability in fluoride levels in infant formulas is ascribed to the choice of the water source employed in the preparation process. This underscores the paramount importance of meticulously adhering to recommendations and guidelines provided by healthcare professionals concerning the utilization of these formulas and their meticulous reconstitution.

Keywords: fluoride; fluorosis; formula milk; milk.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Kumar V., Gaunkar R., Thakker J., Ankola A.V., Iranna Hebbal M., Khot A.J.P., Goyal V., Ali A., Eldwakhly E. Pediatric Dental Fluorosis and Its Correlation with Dental Caries and Oral-Health-Related Quality of Life: A Descriptive Cross-Sectional Study among Preschool Children Living in Belagavi. Children. 2023;10:286. doi: 10.3390/children10020286. - DOI - PMC - PubMed
    1. Lubojanski A., Piesiak-Panczyszyn D., Zakrzewski W., Dobrzynski W., Szymonowicz M., Rybak Z., Mielan B., Wiglusz R.J., Watras A., Dobrzynski M. The Safety of Fluoride Compounds and Their Effect on the Human Body—A Narrative Review. Materials. 2023;16:1242. doi: 10.3390/ma16031242. - DOI - PMC - PubMed
    1. Buzalaf M.A.R. Review of Fluoride Intake and Appropriateness of Current Guidelines. Adv. Dent. Res. 2018;29:157–166. doi: 10.1177/0022034517750850. - DOI - PubMed
    1. Vélez-León E.M., Albaladejo-Martínez A., Ortíz-Ortega P., Cuenca-León K., Armas-Vega A., Melo M. Distribution of Dental Fluorosis in the Southern Zone of Ecuador: An Epidemiological Study. Dent. J. 2023;11:71. doi: 10.3390/dj11030071. - DOI - PMC - PubMed
    1. Carey C.M. Focus on Fluorides: Update on the Use of Fluoride for the Prevention of Dental Caries. J. Evid. -Based Dent. Pract. 2014;14:95–102. doi: 10.1016/j.jebdp.2014.02.004. - DOI - PMC - PubMed

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