Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec 10;15(24):5785.
doi: 10.3390/cancers15245785.

One-Year Follow-Up after Multimodal Prehabilitation Interventions in Radical Cystectomy

Bente Thoft Jensen  1   2 , Jørgen Bjerggaard Jensen  1   3
Affiliations

One-Year Follow-Up after Multimodal Prehabilitation Interventions in Radical Cystectomy

Bente Thoft Jensen et al. Cancers (Basel). .

Abstract

Multimodal prehabilitation is the process of enhancing physiological, nutritional, and psychological resilience to increase patients' functional capacity before major cancer surgery and aims to empower the patient to withstand the pending stress of major surgery and ultimately to improve long-term outcomes. The effect of physical prehabilitation to counteract the physical decline in surgical cancer patients has been documented; however, long-term results have not yet been published. This follow-up study aims to evaluate 1-year results on the efficacy of physical prehabilitation after bladder cancer surgery. The efficacy of prehabilitation was measured over the course of 1 year in 107 patients randomized to (1) pre- and rehabilitation or (2) standard care divided by n = 50 in the intervention (I) and n = 57 in the standard group (S). Physical function was measured by muscle leg power, and nutritional status was expressed with handgrip strength. Prehabilitation in major bladder cancer surgery can significantly improve physical function with 19.8 Watt/kg (p = 0.04), lean body mass (p = 0.047) and body cell mass (p = 0.03), and regained nutritional status one year after surgery. The results demonstrate that the restoration of physical function is vital to a full recovery.

Keywords: ERAS; bladder cancer; exercises; nutritional care; prehabilitation; radical cystectomy; survivorship.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Functional status over the course of 1 year after radical cystectomy measured with leg muscle power and handgrip strength in 107 patients undergoing radical cystectomy at Aarhus University Hospital (2011–2014) (intention-to-treat approach).
See this image and copyright information in PMC

References

    1. Witjes J.A., Bruins H.M., Cathomas R., Compérat E.M., Cowan N.C., Gakis G., Hernández V., Linares Espinós E., Lorch A., Neuzillet Y., et al. European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2020 Guidelines. Eur. Urol. 2021;79:82–104. doi: 10.1016/j.eururo.2020.03.055. - DOI - PubMed
    1. Novara G., Catto J.W., Wilson T., Annerstedt M., Chan K., Murphy D.G., Motttrie A., Peabody J.O., Skinner E.C., Wiklund P.N., et al. Systematic review and cumulative analysis of perioperative outcomes and complications after robot-assisted radical cystectomy. Eur. Urol. 2015;67:376–401. doi: 10.1016/j.eururo.2014.12.007. - DOI - PubMed
    1. Minnella E.M., Awasthi R., Bousquet-Dion G., Ferreira V., Austin B., Audi C., Tanguay S., Aprikian A., Carli F., Kassouf W. Multimodal Prehabilitation to Enhance Functional Capacity Following Radical Cystectomy: A Randomized Controlled Trial. Eur. Urol. Focus. 2021;7:132–138. doi: 10.1016/j.euf.2019.05.016. - DOI - PubMed
    1. Silver J.K., Baima J. Cancer prehabilitation: An opportunity to decrease treatment-related morbidity, increase cancer treatment options, and improve physical and psychological health outcomes. Am. J. Phys. Med. Rehabil./Assoc. Acad. Physiatr. 2013;92:715–727. doi: 10.1097/PHM.0b013e31829b4afe. - DOI - PubMed
    1. Carli F., Awasthi R., Gillis C., Kassouf W. Optimizing a frail elderly patient for radical cystectomy with a prehabilitation program. Can. Urol. Assoc. J. J. L’associat. Urol. Can. 2014;8:E884–E887. doi: 10.5489/cuaj.2025. - DOI - PMC - PubMed

LinkOut - more resources