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Review
. 2023 Dec 12;15(24):5816.
doi: 10.3390/cancers15245816.

Radiogenomics: Contemporary Applications in the Management of Rectal Cancer

Niall J O'Sullivan  1   2   3 , Hugo C Temperley  4 , Michelle T Horan  1   2   3 , Alison Corr  1 , Brian J Mehigan  2   4 , John O Larkin  2   4 , Paul H McCormick  2   4 , Dara O Kavanagh  5   6 , James F M Meaney  1   3 , Michael E Kelly  2   4   7
Affiliations
Review

Radiogenomics: Contemporary Applications in the Management of Rectal Cancer

Niall J O'Sullivan et al. Cancers (Basel). .

Abstract

Radiogenomics, a sub-domain of radiomics, refers to the prediction of underlying tumour biology using non-invasive imaging markers. This novel technology intends to reduce the high costs, workload and invasiveness associated with traditional genetic testing via the development of 'imaging biomarkers' that have the potential to serve as an alternative 'liquid-biopsy' in the determination of tumour biological characteristics. Radiogenomics also harnesses the potential to unlock aspects of tumour biology which are not possible to assess by conventional biopsy-based methods, such as full tumour burden, intra-/inter-lesion heterogeneity and the possibility of providing the information of tumour biology longitudinally. Several studies have shown the feasibility of developing a radiogenomic-based signature to predict treatment outcomes and tumour characteristics; however, many lack prospective, external validation. We performed a systematic review of the current literature surrounding the use of radiogenomics in rectal cancer to predict underlying tumour biology.

Keywords: oncology; radiogenomics; radiomics; rectal cancer; recurrence; survival; treatment response.

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Conflict of interest statement

This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. The authors report no conflict of interest.

References

    1. Sauer R., Becker H., Hohenberger W., Rodel C., Wittekind C., Fietkau R., Martus P., Tschmelitsch J., Hager E., Hess C.F., et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N. Engl. J. Med. 2004;351:1731–1740. doi: 10.1056/NEJMoa040694. - DOI - PubMed
    1. Kong J.C., Soucisse M., Michael M., Tie J., Ngan S.Y., Leong T., McCormick J., Warrier S.K., Heriot A.G. Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer: A Systematic Review and Metaanalysis of Oncological and Operative Outcomes. Ann. Surg. Oncol. 2021;28:7476–7486. doi: 10.1245/s10434-021-09837-8. - DOI - PubMed
    1. Guida A.M., Sensi B., Formica V., D’Angelillo R.M., Roselli M., Del Vecchio Blanco G., Rossi P., Capolupo G.T., Caricato M., Sica G.S. Total neoadjuvant therapy for the treatment of locally advanced rectal cancer: A systematic minireview. Biol. Direct. 2022;17:16. doi: 10.1186/s13062-022-00329-7. - DOI - PMC - PubMed
    1. Ali F., Keshinro A., Weiser M.R. Advances in the treatment of locally advanced rectal cancer. Ann. Gastroenterol. Surg. 2021;5:32–38. doi: 10.1002/ags3.12389. - DOI - PMC - PubMed
    1. Nacion A.J.D., Park Y.Y., Kim N.K. Contemporary management of locally advanced rectal cancer: Resolving issues, controversies and shifting paradigms. Chin. J. Cancer Res. 2018;30:131–146. doi: 10.21147/j.issn.1000-9604.2018.01.14. - DOI - PMC - PubMed

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