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Review
. 2023 Dec 14;15(24):5832.
doi: 10.3390/cancers15245832.

The Role of Pentraxin 3 in Gastrointestinal Cancers

Monika Zajkowska  1 , Barbara Mroczko  1   2
Affiliations
Review

The Role of Pentraxin 3 in Gastrointestinal Cancers

Monika Zajkowska et al. Cancers (Basel). .

Abstract

Gastrointestinal cancers have become a huge problem worldwide as the number of new cases continues to increase. Due to the growing need to explore new biomarkers and therapeutic targets for the detection and treatment of cancerous lesions, we sought to elucidate the role of Pentraxin-3 in the progression of cancerous lesions, as it is involved in the process of angiogenesis and inflammation. Statistically significant changes in the concentration of this parameter have emerged in many gastrointestinal cancer patients. Moreover, it is related to the advancement of cancer, as well as processes leading to the development of those changes. In the case of studies concerning tissue material, both increased and decreased tissue expression of the tested parameter were observed and were dependent on the type of cancer. In the case of cell lines, both human and animal, a significant increase in Pentraxin 3 gene expression was observed, which confirmed the changes observed at the protein level. In conclusion, it can be assumed that PTX3, both at the level of gene expression and protein concentrations, is highly useful in the detection of gastrointestinal cancers, and its use as a biomarker and/or therapeutic target may be useful in the future.

Keywords: GI cancers; PTX-3; colorectal; esophageal; gallbladder; liver; pancreatic; small intestine; stomach.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Functions of Pentraxin 3. Abbreviations: ↑—promotory effect of PTX3; ↓—inhibitory effect of PTX3.
Figure 2
Figure 2
Schematic illustration of articles included in the review.
See this image and copyright information in PMC

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