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Review
. 2023 Nov 30;13(12):1723.
doi: 10.3390/biom13121723.

BODIPY-Based Molecules for Biomedical Applications

Sarasija Das  1 , Sudipto Dey  2 , Sanujit Patra  3 , Arindam Bera  3 , Totan Ghosh  3 , Bibin Prasad  4 , Kapil Dev Sayala  5 , Krishnendu Maji  3 , Anjan Bedi  6 , Sashi Debnath  6
Affiliations
Review

BODIPY-Based Molecules for Biomedical Applications

Sarasija Das et al. Biomolecules. .

Abstract

BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) derivatives have attracted attention as probes in applications like imaging and sensing due to their unique properties like (1) strong absorption and emission in the visible and near-infrared regions of the electromagnetic spectrum, (2) strong fluorescence and (3) supreme photostability. They have also been employed in areas like photodynamic therapy. Over the last decade, BODIPY-based molecules have even emerged as candidates for cancer treatments. Cancer remains a significant health issue world-wide, necessitating a continuing search for novel therapeutic options. BODIPY is a flexible fluorophore with distinct photophysical characteristics and is a fascinating drug development platform. This review provides a comprehensive overview of the most recent breakthroughs in BODIPY-based small molecules for cancer or disease detection and therapy, including their functional potential.

Keywords: BODIPY; BODIPY dyes; BODIPY-based functional materials for medical use; fluorescent probe.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Core structure of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY, left) and references searched with the phrase “BODIPY” in scifinder-n.cas.org (right).
Figure 2
Figure 2
Longer-wavelength absorbing/emitting BODIPY-based fluorophores.
Figure 3
Figure 3
BODIPY-based probes for monitoring aggregation and conformational changes of amyloid-β.
Figure 4
Figure 4
BODIPY-based probes for the detection of reactive oxygen species.
Figure 5
Figure 5
BODIPY-based probes for cancer detection.
Figure 6
Figure 6
BODIPY derivatives for PDT and PTT applications.
See this image and copyright information in PMC

References

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