Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Nov 25;12(12):1661.
doi: 10.3390/antibiotics12121661.

Coagulase-Negative Staphylococci as an Etiologic Agent of Ovine Mastitis, with a Focus on Subclinical Forms

Marios Lysitsas  1 , Vassiliki Spyrou  2 , Charalambos Billinis  1 , George Valiakos  1
Affiliations
Review

Coagulase-Negative Staphylococci as an Etiologic Agent of Ovine Mastitis, with a Focus on Subclinical Forms

Marios Lysitsas et al. Antibiotics (Basel). .

Abstract

The objective of this review is to investigate the distribution and the characteristics of coagulase-negative Staphylococci (CoNS) implicated in ovine mastitis, and especially in subclinical cases, in order to provide a global perspective of the current research data and analyze specific critical aspects of the issue. PRISMA guidelines were implemented in the search of the last 20 years of the related literature in two databases. In total, 139 studies were included in this review. Relevant data were tracked down, assembled, and compared. Regarding the geographical distribution, most studies originated from Europe (68), followed by South America (33). Lacaune was the most examined breed, while S. epidermidis was the predominantly identified species, representing approximately 39% of the obtained isolates. Antibiotic resistance in the relevant bacteria was documented mostly for Penicillin (32.8%) and Amoxicillin (32.1%), while biofilm- and toxin-associated genes were encountered in variable rates because significant inequalities were observed between different articles. Significantly higher rates of antimicrobial resistance were detected in Asia and South America compared to Europe. Finally, the diagnostic procedures carried out in the respective studies were evaluated. Conventional culture and biochemical tests were mostly performed for simple strain identification; therefore, further molecular investigation of isolates should be pursued in future studies, as this will provide important data regarding specific aspects of the implication of CoNS in ovine mastitis.

Keywords: PRISMA guidelines; antibiotic resistance; coagulase-negative Staphylococci; diagnostic procedures; ovine mastitis; subclinical mastitis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Distribution of the studies (countries in shades of blue) included in this review throughout the world. Color indicates the arithmetical range to which the number of relevant articles from the corresponding country belongs. (https://www.mapchart.net/world.html, accessed οn 20 September 2023).
Figure 2
Figure 2
Identification of studies regarding CoNS and ovine mastitis via databases using the PRISMA guidelines [157].
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Selvaggi M., D’Alessandro A.G., Dario C. Environmental and Genetic Factors Affecting Milk Yield and Quality in Three Italian Sheep Breeds. J. Dairy Res. 2017;84:27–31. doi: 10.1017/S0022029916000765. - DOI - PubMed
    1. Vasileiou N.G.C., Chatzopoulos D.C., Sarrou S., Fragkou I.A., Katsafadou A.I., Mavrogianni V.S., Petinaki E., Fthenakis G.C. Role of Staphylococci in Mastitis in Sheep. J. Dairy Res. 2019;86:254–266. doi: 10.1017/S0022029919000591. - DOI - PubMed
    1. Gelasakis A.I., Mavrogianni V.S., Petridis I.G., Vasileiou N.G.C., Fthenakis G.C. Mastitis in Sheep—The Last 10 Years and the Future of Research. Vet. Microbiol. 2015;181:136–146. doi: 10.1016/j.vetmic.2015.07.009. - DOI - PubMed
    1. Libera K., Konieczny K., Grabska J., Smulski S., Szczerbal I., Szumacher-Strabel M., Pomorska-Mól M. Potential Novel Biomarkers for Mastitis Diagnosis in Sheep. Animals. 2021;11:2783. doi: 10.3390/ani11102783. - DOI - PMC - PubMed
    1. Fragkou I.A., Boscos C.M., Fthenakis G.C. Diagnosis of Clinical or Subclinical Mastitis in Ewes. Small Rumin. Res. 2014;118:86–92. doi: 10.1016/j.smallrumres.2013.12.015. - DOI

LinkOut - more resources