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. 2023 Nov 24;13(12):1629.
doi: 10.3390/brainsci13121629.

Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid Consumption

Aleksander Turczynowicz  1 , Piotr Jakubów  1 , Karolina Niedźwiecka  2 , Julia Kondracka  1 , Weronika Pużyńska  3 , Mariola Tałałaj  1 , Tomasz Guszczyn  4 , Paweł Grabala  4 , Oksana Kowalczuk  5 , Szymon Kocańda  2
Affiliations

Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid Consumption

Aleksander Turczynowicz et al. Brain Sci. .

Abstract

Children constitute a special group in pain therapy. Single nucleotide polymorphisms that are associated with differences in postoperative, inflammatory pain perception and opioid requirement are the A118G SNP in the mu-opioid receptor 1 (OPRM1) gene and the rs1205 CRP. This study aimed to determine connection between OPRM1 and rs1205 CRP SNPs in pediatric patients postoperatively and pain intensity, the opioid dose needed to control pain after scoliosis correction, and other clinical aspects. Genotypes of rs1205 CRP and OPRM1 polymorphisms in a sample of 31 patients were specified, and statistical analysis was performed in terms of age, genotype frequency, pain assessment, sufentanil flow, post-anesthesia care unit stay, and the use of coanalgesics. The frequency of A/A and A/G genotypes in the OPRM1 gene was in line with 1000Genomes data for the European population. Patients from the AG group of OPRM1 SNP more frequently required coanalgesics for adequate pain control; however, it was of weak statistical significance. Other parameters measured in the study were not statistically significant in relation to OPRM1 and CRP polymorphisms. The effect of SNPs on postoperative pain management and opioid therapy in children was not confirmed by this study. An expansion of the study sample and other opioid-related SNPs is required.

Keywords: SNP; acute pain; oprm1; postoperative pain; single nucleotide polymorphism.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
A/A genotype is more frequently present than A/G genotype among studied sample of Central Europeans (p = 0.001).
Figure 2
Figure 2
Coanalgesics administration frequency (%).
Figure 3
Figure 3
Pain intensity after extubation is higher in A/G than A/A genotype.
Figure 4
Figure 4
rs1205 SNP genotype frequencies (%).
See this image and copyright information in PMC

References

    1. Niv D., Devor M. Chronic Pain as a Disease in Its Own Right. Pain Pract. 2004;4:179–181. doi: 10.1111/j.1533-2500.2004.04301.x. - DOI - PubMed
    1. Zieliński J., Morawska-Kochman M., Zatoński T. Pain Assessment and Management in Children in the Postoperative Period: A Review of the Most Commonly Used Postoperative Pain Assessment Tools, New Diagnostic Methods and the Latest Guidelines for Postoperative Pain Therapy in Children. Adv. Clin. Exp. Med. 2020;29:365–374. doi: 10.17219/acem/112600. - DOI - PubMed
    1. Morton N.S. Management of Postoperative Pain in Children. Arch. Dis. Child.—Educ. Pract. 2007;92:ep14–ep19. doi: 10.1136/adc.2004.070888. - DOI - PubMed
    1. Astuto M., Rosano G., Rizzo G., Disma N., Di Cataldo A. Methodologies for the Treatment of Acute and Chronic Nononcologic Pain in Children. Minerva Anestesiol. 2007;73:459–465. - PubMed
    1. Taylor E.M., Boyer K., Campbell F.A. Pain in Hospitalized Children: A Prospective Cross-Sectional Survey of Pain Prevalence, Intensity, Assessment and Management in a Canadian Pediatric Teaching Hospital. Pain Res. Manag. 2008;13:25–32. doi: 10.1155/2008/478102. - DOI - PMC - PubMed