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Review
. 2023 Nov 27;11(12):3151.
doi: 10.3390/biomedicines11123151.

Natural Compounds of Salvia L. Genus and Molecular Mechanism of Their Biological Activity

Gaziza Zhumaliyeva  1 , Aizhan Zhussupova  1 , Galiya E Zhusupova  2 , Ewelina Błońska-Sikora  3 , Antonella Cerreto  4 , Nargul Omirbekova  1 , Zhazira Zhunusbayeva  1 , Nadezhda Gemejiyeva  5 , Madina Ramazanova  5 , Małgorzata Wrzosek  6 , Samir A Ross  7   8
Affiliations
Review

Natural Compounds of Salvia L. Genus and Molecular Mechanism of Their Biological Activity

Gaziza Zhumaliyeva et al. Biomedicines. .

Abstract

The study of medicinal plants is important, as they are the natural reserve of potent biologically active compounds. With wide use in traditional medicine and the inclusion of several species (as parts and as a whole plant) in pharmacopeia, species from the genus Salvia L. are known for the broad spectrum of their biological activities. Studies suggest that these plants possess antioxidant, anti-inflammatory, antinociceptive, anticancer, antimicrobial, antidiabetic, antiangiogenic, hepatoprotective, cognitive and memory-enhancing effects. Phenolic acids, terpenoids and flavonoids are important phytochemicals, which are primarily responsible for the medicinal activity of Salvia L. This review collects and summarizes currently available data on the pharmacological properties of sage, outlining its principal physiologically active components, and it explores the molecular mechanism of their biological activity. Particular attention was given to the species commonly found in Kazakhstan, especially to Salvia trautvetteri Regel, which is native to this country.

Keywords: Kazakhstan; physiologically active components; sage species.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The summary of the novel therapeutic effects and pharmacological properties of Salvia species and the impact on molecular pathways. Possible places of inhibition (−) and activation (+) by Salvia species.
See this image and copyright information in PMC

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