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. 2023 Dec 4;59(12):2117.
doi: 10.3390/medicina59122117.

Histopathologic and Preneoplastic Changes in Tubal Ligation Materials

Ethem Ömeroğlu  1 , Yaşar Ünlü  1 , Ayşe Nur Uğur Kılınç  1 , Tuğba Günler  1 , Oğuzhan Günenc  2
Affiliations

Histopathologic and Preneoplastic Changes in Tubal Ligation Materials

Ethem Ömeroğlu et al. Medicina (Kaunas). .

Abstract

Background and Objectives: To investigate histopathological changes and serous carcinoma precursors such as secretory cell outgrowths (SCOUTs) and p53 signature in the bilateral tubal ligation (BTL) materials used during cesarean section (S/C). Materials and Methods: In total, 138 patients underwent S/C and tubal sterilization (TS) between October 2020 and May 2021 at Konya City Hospital. Patients' data were obtained from the hospital's system. All data and findings were investigated and statistically evaluated. Results: The mean age was 34.62 years (22-44), the mean gravity was 4.89 (2-15) and the mean parity was 3.46 (1-10). In total, 5.79% SCOUT, 7.24% atypia and 9.42% p53 signatures were observed. Significant correlations were shown between the epithelial cell lineage and age between Ki-67, SCOUT, and gravity; between the Ki-67 results and gravity and parity; and between the p53 score and age. Conclusions: TS is a common, safe, and effective method worldwide. Today, BTL is increasing along with increasing S/C ratios. In addition to the reduced risk of ovarian cancers with ligation alone, precursor lesions such as hyperplasia, SCOUT, p53 signature, and STIL/Serous tubal intraepithelial carcinoma (STIC) are encountered in the ampulla materials obtained. Considering the low rates of re-anastomosis, tubal excision may be recommended instead of ligation in women of relatively higher gravity and age.

Keywords: SCOUT; epithelial hyperplasia; p53 signature; tubal ligation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Intra-epithelial lymphocytes (arrows) (A); epithelial hyperplasia (arrows) (B).
Figure 2
Figure 2
Atypical changes (arrows) (A), very low p53 (B), and KI-67 (C) values.
Figure 3
Figure 3
Secretory cell outgrowths (SCOUTs) (arrows) (A), p53 signature (arrows) (B), low Ki-67 index Score 1 (C).
Figure 4
Figure 4
Extra findings. Decidua (arrows) in tubal tissue (A), Walthard remnants (arrows) (B), paratubal cyst (arrows) (C).
See this image and copyright information in PMC

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References

    1. Sung S., Abramovitz A. StatPearls. StatPearls Publishing; Treasure Island, FL, USA: 2022. Tubal Ligation. - PubMed
    1. Şentürk M.B., Budak M.S., Toğrul C., Tahaoğlu A.E., Balsak D., Akgöl S. The Pregnancy Rates After Tubal Reanastomosis. Okmeydanı Tıp Derg. 2016;32:79–82. doi: 10.5222/otd.2016.1044. - DOI
    1. Özkan H., Özer B.U., Arı Ö. Sezaryen İle Doğuma Güncel Bir Bakış: Modern Sezaryen Teorisi. Arşiv Kaynak Tarama Derg. 2021;30:226–235.
    1. Uaamnuichai S., Phutrakool P., Thammasitchai N., Sathitloetsakun S., Santibenchakul S., Jaisamrarn U. Does socioeconomic factors and healthcare coverage affect postpartum sterilization uptake in an urban, tertiary hospital? Reprod. Health. 2023;20:23. doi: 10.1186/s12978-023-01572-5. - DOI - PMC - PubMed
    1. Ely L.K., Truong M. The role of opportunistic bilateral salpingectomy vs tubal occlusion or ligation for ovarian cancer prophylaxis. J. Minim. Invasive Gynecol. 2017;24:371–378. doi: 10.1016/j.jmig.2017.01.001. - DOI - PubMed