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. 2023 Dec 5;28(24):7956.
doi: 10.3390/molecules28247956.

Chemical Constituents and α-Glucosidase Inhibitory, Antioxidant and Hepatoprotective Activities of Ampelopsis grossedentata

Qu-Jing Luo  1 , Wen-Chao Zhou  1 , Xin-Yi Liu  1 , Ya-Jie Li  1 , Qing-Ling Xie  1 , Bin Wang  1 , Chao Liu  1   2 , Wen-Mao Wang  1   2 , Wei Wang  1 , Xu-Dong Zhou  1
Affiliations

Chemical Constituents and α-Glucosidase Inhibitory, Antioxidant and Hepatoprotective Activities of Ampelopsis grossedentata

Qu-Jing Luo et al. Molecules. .

Abstract

Ampelopsis grossedentata is a valuable medicinal and edible plant, which is often used as a traditional tea by the Tujia people in China. A. grossedentata has numerous biological activities and is now widely used in the pharmaceutical and food industries. In this study, two new flavonoids (1-2) and seventeen known compounds (3-19) were isolated and identified from the dried stems and leaves of A. grossedentata. These isolated compounds were characterized by various spectroscopic data including mass spectrometry and nuclear magnetic resonance spectroscopy. All isolates were assessed for their α-glucosidase inhibitory, antioxidant, and hepatoprotective activities, and their structure-activity relationships were further discussed. The results indicated that compound 1 exhibited effective inhibitory activity against α-glucosidase, with an IC50 value of 0.21 μM. In addition, compounds 1-2 demonstrated not only potent antioxidant activities but also superior hepatoprotective properties. The findings of this study could serve as a reference for the development of A. grossedentata-derived products or drugs aimed at realizing their antidiabetic, antioxidant, and hepatoprotective functions.

Keywords: Ampelopsis; Ampelopsis grossedentata; antioxidant; flavonoids; hepatoprotective activity; α-glucosidase inhibitory.

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Conflict of interest statement

Author Xu-Dong Zhou has received research grants from Hunan Qiankun Biotechnology Co., Ltd. Author Xu-Dong Zhou has been involved as an expert witness in Hunan Qiankun Biotechnology Co., Ltd.

Figures

Figure 1
Figure 1
Structures of isolated compounds from the leaves of A. grossedentata.
Figure 2
Figure 2
Key HMBC and 1H-1H COSY correlations of compounds 1–2.
Figure 3
Figure 3
Hepatoprotective activity of compounds 1–19 (20 μM). Note: n = 3, mean ± SD. Compared with the control: ### p < 0.001; compared with the APAP: ** p < 0.01 and *** p < 0.001.
See this image and copyright information in PMC

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